Speckle tracking derived left and right ventricular strain, strain rate and
Rima Sileikiene, Jolanta Vaskelyte, Vaida Mizariene, Irena Nedzelskiene, Renaldas Jurkevicius, Viktorija Sileikyte, Rimantas Kevalas
J Clin Exp Invest 2011;2(1):1-10.
https://doi.org/10.5799/ahinjs.01.2011.01.0202
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: Aim of the study was to assess left and right ventricular strain, strain rate and left ventricular rotation in children at late follow-up after atrioventricular node slow pathway radiofrequency ablation.
Materials and methods: Left and right ventricular strain, strain rate, left ventricular rotation, rotational ve-locity and twist were assessed using the speckle tracking echocardiography in 22 children who underwent radiofrequency ablation of slow pathway and in 15 healthy control children.
Results: There were no significant differences in conventional echocardiographic left and right ventricular parameters between the two groups (p>0.05), except left atrial volume (28.0±8.7 ml in control group vs. 37.3±13.9 ml in radiofrequency ablation group, p=0.024) and right atrial volume (16.0±6.7 ml vs. 21.5±8.5 ml, respectively, p=0.047) and their left (16.7±6.0 ml/m2 vs. 26.3± 9.8 ml/m2, p=0.002, respectively) and right (16.0± 6.6 ml/m2 vs. 21.5±8.5 ml/m2, respectively, p=0.05) indices that were significantly higher in radiofrequency ablation group. Speckle tracking imaging derived regional and global strain, systolic and diastolic left and right ventricular strain rate as well as left ventricular rotation, rotational rate did not differ between the radiofrequency ablation group and controls (p>0.05). Left ventricular twist was comparable between the radiofrequency ablation group and controls (p>0.05).
Conclusions: Speckle tracking echocardiography did not revealed any deterioration of regional and global long and short axis function of the left and right ventricles in children, who underwent atrioventricu-lar node slow pathway radiofrequency ablation.
Keywords: Speckle tracking, radiofrequency ablation, children, echocardiography
Thallium poisoning: Clinical observations through two outbreaks in Basrah
Khalil I. Al-Hamdi, Ahmed A. Al-Mohammadi
J Clin Exp Invest 2011;2(1):11-15.
https://doi.org/10.5799/ahinjs.01.2011.01.0203
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: Thallium is one of the most suitable agents for criminal poisoning of human as it is tasteless and odorless. The aim of this study was to report clinical features of thallium poisoning in two outbreaks.
Materials and methods: This case descriptive study was conducted in Basrah Teaching Hospital from January 2009 to February 2010, where a total of 32 patients with thallium poisoning were enrolled. At the first outbreak, poisoning occurred due to ingestion of cake, while the second outbreak was due to acci-dental ingestion of rat poisons. A detailed history was taken and complete clinical examination was per-formed. Thallium in urine was measured using the colorimetric method and was found as positive in all patients.
Results: Thirty two patients were evaluated. The first outbreak included 17 patients (mean age 24 years), and the second outbreak included 15 patients (mean age15 years). Among both outbreaks the derma-tological findings were mainly hair loss in diffuse and patchy pattern affected the scalp and limbs. Also dusky ecchymotic red dermatitis like rash was observed on the face, especially perioral region and dor-sum of hands and legs. Neurologic manifestations, mainly of peripheral neuropathy, were seen in 50% patients of the second group. Patients erroneously had received zinc-sulphate before correct diagnosis. Thirty patients were improved and two died.
Conclusion: Outbreak of thallium poisoning may be result of accidental ingestion or criminal purposes. It gives characteristic cutaneous, neurological and psychological features that can lead to the definite diag-nosis.
Keywords: Thallium poisoning, clinical findings, diagnosis, outbreak, Basrah
Sympathetic skin responses in migraineurs
Aysel Milanlıoğlu, Temel Tombul
J Clin Exp Invest 2011;2(1):16-21.
https://doi.org/10.5799/ahinjs.01.2011.01.0204
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: The aim of this study was to compare the sympathetic nerve system profile of migraineurs during the headache-free periods to a group of normal subjects based on sympathetic skin response.
Materials and methods: 82 patients with migraine (20 migraine with aura and 62 without aura) and 35 healthy volunteers who are age-and sex-matched patients with migraine selected randomly from the hospital personnel as a control group were enrolled in the study. Patients reporting at least one of the autonomic symptoms during the attack periods regularly were considered migraineurs with having autonomic symptoms. Sympathetic skin response test was applied on both sides of the upper and lower limbs of all subjects.
Results: There were no subjects whose responses were absent for both right and left sides of upper and lower limbs. Patients with migraine had significantly longer sympathetic skin response latency than the control group. There was no significant difference between the mean latency and amplitude results in the migraine patients with and without aura or autonomic dysfunction or not (P>0.05). Additionally, sympathetic skin response amplitude values were not significantly different between the three groups (P>0.05).
Conclusions: Migraine patients exhibited significantly longer sympathetic skin response latency than controls, leading to suggest that sympathetic hypofunction occurred in patients with migraine during the headache-free period.
Keywords: Sympathetic skin response, migraine, autonomic nerve system
Effects of unilateral spinal anesthesia with low dose bupivacaine and bupivacaine-fentanyl combination on recovery
Bilgehan Sönmez, Murat Akçay, Erkan Yavuz Akçaboy, Zeynep Nur Akçaboy, Ahmet Küçük
J Clin Exp Invest 2011;2(1):22-29.
https://doi.org/10.5799/ahinjs.01.2011.01.0205
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: Our aim was to compare unilateral spinal anesthesia produced by 6 mg hyperbaric bupivacaine or 4 mg hyperbaric bupivacaine plus 10 µg fentanyl for day-case arthroscopic knee surgery.
Material and methods: In this study we evaluated hemodynamic effects, block levels, and recovery characteristics. After approval of Institutional Ethics Committee, ASA I-II, 42 patients were enrolled into the study. Patients were randomly allocated in two groups. Group I (n=22) 6 mg hyperbaric bupivacaine+10µg fentanyl, group II (n=22) 4 mg hyperbaric bupivacaine+10µg fentanyl. The patients were applied standard monitoring, and hemodynamic parameters were recorded. Then spinal anesthesia was performed with the patient lateral decubitis position, using a 25 G Quincke spinal needle at the L3-4 intervertebral space. Parameters below were recorded for each patient: hemodynamic, time to reach to level of T12 dermatome, maximum sensory level, motor block levels and recovery characteristics level of motor block, level of sensory block, time to reach T12 dermatome.
Results: Demographic and hemodynamic variables were not different between groups (p>0.05). Although level of sensory block, and time to reach T12 dermatome were not different (p>0.05), level of motor block, ambulation time and time to discharge were significantly longer in Group I than Group II (p<0.05). Side effects were not different between groups, except more itching in Group II.
Conclusion: Spinal anesthesia with using 4 mg hyperbaric bupivacaine+10µg fentanyl outpatients undergoing knee surgery may have superiority comparing with 6 mg hyperbaric bupivacaine+10µg fentanyl for recovery characteristics.
Keywords: Arthroscopy, spinal anesthesia, bupivacaine, fentanyl, recovery
Outcomes of the congenital clubfoot deformity treated by Ponseti’s method
İbrahim Azboy, Güzelali Özdemir, Sinan Zehir, Ahmet Şükrü Mercan, Abdullah Demirtaş
J Clin Exp Invest 2011;2(1):30-34.
https://doi.org/10.5799/ahinjs.01.2011.01.0206
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: The purpose of this study was to evaluate our result in patients with congenital clubfoot deformity who had been treated with Ponseti’s technique.
Materials and methods: The study included 28 patients (18 males, 10 females, mean age 2.2 months; range 6 days to 5 months). All patients had Dimeglio grade II, III, and IV deformities. All patients had manipulation and casting according to the Ponseti’s technique. Achilles tenotomy was performed in the persistent equines. Maintenance of correction was obtained with the use of foot abduction orthosis. Mean follow-up period was 17 months (range 6-36 months).
Results: Forty-one feet of 28 patients were treated according to the Ponseti’s technique. Achilles tenotomy was performed in 31 feet (81%). Posterior release was not performed in any patient. Although, correction was maintained in all feet at the beginning, 14 feet (31%) were relapsed. The relapses were due to decreased compliance to foot abduction orthoses.
Conclusion: Ponseti technique is an effective, and reliable in correction of idiopatic congenital clubfoot deformity. The results also suggest that the role of family education to enhance compliance to brace application and experienced orthotist are important to prevent relapses.
Keywords: Congenital clubfoot deformity, Ponseti’s method, treatment outcomes
The effect of swimming on pulmonary functions, blood pressure and body composition
İsmail Gökhan, Recep Kürkçü, Sebahattin Devecioğlu
J Clin Exp Invest 2011;2(1):35-41.
https://doi.org/10.5799/ahinjs.01.2011.01.0207
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: The aim of this study was to investigate the effect of 8 week swimming exercise on adult sedentary men’s respiratory functions, resting heart rate, blood pressures and body composition.
Materials and methods: A total of 80 volunteers (40 in the study group, 40 in the control group), aged between 20 and 29 years were included. The participants’ body weight, percentage of body fat (PBF), body mass index (BMI), resting heart rate (RHR), systolic (SBP) and diastolic blood pressures (DBP), and respiratory functions were measured before and after 8 week of swimming training program and compared with each other.
Results: Significant decreases were observed between pre- and post-exercise (following 8 weeks exercise training) in PBF (18.1±5% vs. 14.3±4%, respectively), RHR (83.1±6/min vs. 74.6±3.8/min), DBP (83±7,2 mmHg vs. 74.6±3,8 mmHg) (p<0.001). Significant increases were observed between pre-test and post-test measurements in forced expiration volume (4.1±0.9 lt vs. 5.4±0.8 lt, respectively), forced vital capacity (4.4±1.1 lt vs. 6±1.1 lt) vital capacity (4.9±1.2 lt vs. 6.6±1.2 lt), maximum voluntarily ventilation (140.6±30.3 lt vs. 185.4±29 lt) (p>0.001). No significant differences were found between pre-test and post-test measurements in body weight (78.1±11.4 kg vs. 75.3±9.9 kg, respectively), BMI (25.2±3.9 kg/m2 vs. 24.3±2.8 kg/m2) and SBP (127.6±11.8 mmHg vs. 115.8±5.1 mmHg) (p>0.05).
Conclusion: Eight weeks swimming exercise reduced the PBF and increased the forced expiration volume, maximum voluntarily ventilation, vital capacity and forced vital capacity. Swimming training also decreased RHR and balanced DBP.
Keywords: Swimming, pulmonary functions, blood pressure, body mass index, exercise
Investigation of Framingham Risk Factors in Turkish adults
Nilgün Tekkeşin, Cumhur Kılınç
J Clin Exp Invest 2011;2(1):42-49.
https://doi.org/10.5799/ahinjs.01.2011.01.0208
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: The aim of this study was to determine 10-year risk for development of cardiovascular diseases using Framingham risk scoring as a tool for the estimation of coronary risk and renew the blood lipid levels.
Materials and methods: Samples from fasting 3169 healthy donors declaring as having no cardiovascular disease and diabetes (1800 women, mean age 46.8±9.2 years) and 1369 men, mean age 46.03±8.4 years) were tested and scored according to risk factors in both genders.
Results: When average values were considered, total cholesterol level was higher (204±42 mg/dL) according to reactive insert reference values. High total kolesterol and low HDL-C levels were seen in 20% and 19.5% of men and 32.6% and 1.1% of women, respectively. The number of participants having systolic blood pressure ≥130 mmHg and diastolic blood pressure ≥ 85 mmHg were 775 (24.5%) and the distribution of those values was 10.6 % in men and 13.9% in women. The mean 10-year cardiovascular disease risks were 9.4 % in men and 4.6% in women among 3169 participants.
Conclusion: A 10-year risk of coronary disease, in Turkish males was 2-fold higher than in Turkish females. Use of Framingham study in clinical assessments maintains to be a valid method in preventive approaches for development of cardiovascular diseases.
Keywords: Framingham risk score, coronary heart disease, HDL-cholesterol, LDL-cholesterol, total cholesterol
Investigation of Entamoeba histolytica in stool specimens by ELISA during a year
Tuba Dal
J Clin Exp Invest 2011;2(1):50-54.
https://doi.org/10.5799/ahinjs.01.2011.01.0209
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: The aim of this study was to investigate Entamoeba histolytica in the stool samples that have been sent to microbiology laboratory by ELISA method.
Materials and methods: This study was performed on 800 stool specimens belonging to different age groups and different patients sent to Microbiology Laboratory of a State Hospital between January 2009 and December 2009.
Results: In this study Entamoeba histolytica/dispar cysts and/or trophozoites were observed in 31 (3.9%) out of a total of 800 stool specimens which were examined by native-lugol. Entamoeba histolytica specific antigen was investigated by ELISA in all stool specimens. Entamoeba histolytica specific antigen was detected in 12 (1.5%) of these stool specimens. The diagnosis of amoebiasis for the patients whose ELISA tests were “positive” and appropriate therapy was begun.
Conclusion: Entamoeba histolytica in the stool samples should be investigated and unnecessary treatments should not given to patients.
Keywords: Entamoeba histolytica/dispar, specific antigen, cyst, trophozoite, ELISA, amoebiasis
The comparison of excisionel biopsies between wire-guided and radioguided occult lesion localization in nonpalpable breast lesions
Kağan Karabulut
J Clin Exp Invest 2011;2(1):55-61.
https://doi.org/10.5799/ahinjs.01.2011.01.0210
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: The development of breast imaging methods increased frequent of nonpalpable breast le-sions. Consequently, diagnosis of early breast cancer increased and breast cancer mortality decreased. Several techniques were described for excisional biopsy of nonpalpable breast lesions. Wire guided local-ization is currently the most commonly used localization method for nonpalpable breast lesions. ROLL is a possible alternative to the commonly used wire guided localization of non palpable breast lesions and ROLL is widespread more and more throughout the world. In this study, wire-guided localization and ROLL were compared for excisional biopsy in nonpalpable breast lesions.
Materials and methods: The study was performed on two groups, each containing 30 subjects. We as-sessed radiographical localization time, operative time, volume of the excised specimen, clearance mar-gins, postoperative pain, and hospital stay, cycle time to normal activation, complications, cost-effectiveness, and comfort assessment of each method in terms of surgeon-patient-radiologist between two groups.
Results: In both of techniques complete lesions were excised. Statistically there were no significant dif-ferences between two groups in terms of specimen excised volume, operation time, postoperative pain, hospital stay, activate stays (p>0.05).
Conclusion: ROLL is a reliable alternative to the wire guided localization.
Keywords: Breast lesions, non-palpable, ROLL, localization, wire-guided
The effect of vitamin C application on liver enzymes and plasma lipid levels in footballers and basketball players
Yüksel Koçyiğit, M. Cüneyt Aksak, Yıldız Atamer, Ayfer Aktaş
J Clin Exp Invest 2011;2(1):62-68.
https://doi.org/10.5799/ahinjs.01.2011.01.0211
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: The aim of this study was to investigate the effects of vitamin C supplementation on the liver enzymes and plasma lipids in footballers and basketball players following three weeks of training and vitamin C supplementation.
Materials and methods: A total of 20 volunteer male sportsmen were included. Blood levels of urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total cholesterol (T.Col), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), very low density lipoprotein (VLDL) and triglyceride before exercise (BE), were measured and the groups were undertaken a 10-minute exercise. After exercise (AE), their values were measured again and they given 1 g/day vitamin C. Three weeks later their BE and AE parameters were measured.
Results: In footballers, after the vitamin C supplementation elevated AST, ALT, ALP and LDH in AE were found compared with BE (P<0.001), while blood urea dropped (P<0.05). In basketball players, the AE values of the AST, ALT and ALP before and after the supplementation of vitamin C were higher compared to those of BE (P<0.001). After the vitamin C administration, higher urea (P<0.05) and lower LDL (P<0.001) levels of BE and AE were found. In basketball players levels of blood urea and AST were found to be elevated compared to footballers both before and after exercise (P<0.001) while LDH dropped (P<0.05) following vitamin C and HDL-C levels were higher in all sportsmen compared with BE. In basketball players LDL-C and triglyceride levels decreased with vitamin C (p<0.01).
Conclusion: Vitamin C supplementation increased HDL-C levels both in footballers and basketball players. In basketball players, LDL-C, triglyceride and LDH levels decreased by vitamin C administration.
Keywords: Vitamin C, football, basketball, plasma lipids
The effect of swimming training on body composition and motoric features in adult sedentary young men
İsmail Gökhan, Recep Kürkçü
J Clin Exp Invest 2011;2(1):69-73.
https://doi.org/10.5799/ahinjs.01.2011.01.0212
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: The aim of this study was to investigate the effect of 8 week of swimming training program on motoric features, resting heart rate, blood pressure, and body composition in young sedentary men.
Materials and methods: Forty volunteers aged between 20 and 29 years participated in the research. The participants’ body weight, percentage of body fat, body mass index, flexibility, push-up, shuttle, horizontal-vertical jump and 20-meter sprint were measured and compared before and after the 8 weeks of swimming training program.
Results: At the end of the study, study groups’ measurements were compared. Significant decreases were observed on parameters of percentage of body fat and 20 m sprint run between pre-post test (p<0.001), however no significant differences were observed in body weight and body mass index (p>0.05). Significant increases were observed on parameters of push-up, vertical jump (p<0.001 and parameter of shuttle (p<0.05) between pre- and post-test results. On the other hand, a significant change was not observed on parameters of flexibility and horizontal jump (p>0.05).
Conclusion: Eight weeks swimming training seems to reduce percentage of body fat. It has been observed that 8 weeks swimming training increased values of push-up, shuttle and vertical jump. On the other hand, no change was observed in values of flexibility and horizontal jump.
Keywords: Motoric features, circulation parameters, sedentary man, swimming exercise, body composition
Intestinal parasites and report of etiological analysis in a state hospital
Erkan Yula, Özcan Deveci, Melek İnci, Alicem Tekin
J Clin Exp Invest 2011;2(1):74-79.
https://doi.org/10.5799/ahinjs.01.2011.01.0213
Research Article
[Abstract]
[PDF]
ABSTRACT
Objectives: Intestinal parasitosis is a major public health problem particularly in the developing countries and affects approximately 4 billion people globally. The presented study aimed to determine the prevalence of multiple (mixt) intestinal parasites and potential source of infection in our region.
Materials and methods: A total of 1,620 stool specimen that sent to Kızıltepe State Hospital Microbiology Laboratory throughout a 4 months period to investigate for parasitic agents were included. Following macroscopic examination, stool specimens were precipitated and examined for intestinal parasites by copro-parasitological methods including native-lugol method. All of stool specimens were investigated for Entamoeba histolytica/dispar screening by Micro-ELISA method using commercial kits regarding with the existence of adhesin antigens.
Results: In this study, a total of 1,620 human stool samples were examined and 447 (27.6%) were found to be favorable for intestinal parasites. Among infected stool samples, 63 (14.1%) were infected with two parasites and 18 (4.0%) with three parasites. The first three most common parasites were Giardia intestinalis (43.3%), Taenia spp. (36.4%) and Trichomonas hominis (5.4%). There was no significant difference between males and females in multiple infected (G. intestinalis & Taenia spp.) stool samples (p>0.05).
Conclusion: Our findings suggested that intestinal parasitic infections remain endemic in our region.
Keywords: Intestinal parasites, etiological analysis, state hospital
Palmoplantar Lichen Planus: A Report of four cases
Derya Uçmak, Ruken Azizoğlu, Mehmet Harman
J Clin Exp Invest 2011;2(1):80-84.
https://doi.org/10.5799/ahinjs.01.2011.01.0214
Research Article
[Abstract]
[PDF]
ABSTRACT
Lichen planus is a benign, inflammatory and itchy dermatosis that is incurred by skin, skin extensions and mucosa. Lichen planus rarely show palmoplantar involvement. Since stratum corneum in palmoplantar lichen planus is extremely thick, lesions can be yellow colored instead of the purple colored papules that are classic lesions. Clinically, it might be confused with psoriasis, secondary syphilis, verruca vulgaris, hyperkeratotic eczema, palmoplantar keratodermas, hyperkeratotic type tinea pedis and xanthomas. In this report, four lichen planus cases were presented who represented palmoplantar involvement.
Keywords: Lichen planus, palmoplantar, hyperkeratosis
Immune thrombocytopenic purpura following Varicella zoster infection
Ali Seçkin Yalçın, Enes Coşkun, Hatice Uyanık, Alper Dai, Ali Bay
J Clin Exp Invest 2011;2(1):85-87.
https://doi.org/10.5799/ahinjs.01.2011.01.0215
Case Report
[Abstract]
[PDF]
ABSTRACT
Although thrombocytopenia is a rarely observed complication following chickenpox, it can lead to serious bleeding problems. In order to underline rare hematologic complications of varicella infection and the importance of vaccination, here we reported a seven year old boy who developed severe thrombocytopenia during varicella infection and gave good response to intravenous immunoglobulin therapy.
Keywords: Varicella, immune thrombocytopenia, outcome
Unilateral absence of the parotid gland: a rare disorder
Salih Bakır, Hatice Gümüş, Aydın Varolgüneş, Faruk Meriç
J Clin Exp Invest 2011;2(1):88-99.
https://doi.org/10.5799/ahinjs.01.2011.01.0216
Case Report
[Abstract]
[PDF]
ABSTRACT
Unilateral agenesis of the parotid gland is an extremely rare disorder. Only a few cases have been reported in the literature. Although this entity is usually asymptomatic, sometimes it may be important. For an example the normal parotid gland can be thought like a tumor due to the facial asymmetry. Accompanied by clinical and radiological findings, we present a case of unilateral parotid gland agenesis without involvement of other major salivary glands and together with a compensatory hypertrophy of the contralateral parotid gland.
Keywords: Parotid gland, agenesis, computed tomography, magnetic resonance imaging
Vocal cord hemangioma in an adult
Cengiz Durucu, Erkan Karataş, Tekin Bağlam, Cengiz Çevik, Muzaffer Kanlıkama
J Clin Exp Invest 2011;2(1):91-94.
https://doi.org/10.5799/ahinjs.01.2011.01.0217
Case Report
[Abstract]
[PDF]
ABSTRACT
Hemangioma is one of the most common benign tumors in the head and neck region. Laryngeal hemangiomas are benign vascular tumors of unknown etiology that arise from subglottic region with stridor in infants. This type also known as congenital laryngeal hemangioma, is the more common. Congenital hemangiomas occur usually in subglottic region and more frequent in girls. Laryngeal hemangioma in adults is a very rare condition and main symptom is hoarseness and breathing difficulties. Adult hemangiomas can be seen in different locations such as the epiglottis, aryepiglottic folds, arytenoids and false and true vocal cords. They are more often of cavernous form and cause hoarseness. In this report we present an adult patient with hemangioma of the left vocal fold and review the literature. Diagnostic investigation revealed a pink-purple mass which was extended from the anterior comissure to the posterior part of true vocal cord and false vocal cord, filling the ventricule and extending to supraglottic region. Direct laryngoscopy was performed, but the lesion was not excised because of its widespread extension in the larynx.
Keywords: Hemangioma, larynx, adult, vocal fold
Giant mesenteric lipoma caused abdominal pain: Report of two cases
Fahri Halit Beşir, Mesut Gül, Erdem Koçak, Kemal Karakaya, Hüseyin Özdemir, Sadi Gündoğdu
J Clin Exp Invest 2011;2(1):95-97.
https://doi.org/10.5799/ahinjs.01.2011.01.0218
Case Report
[Abstract]
[PDF]
ABSTRACT
Mesenteric localization is rare in lipomas which are benign tumors of fat cells and they are generally asymptomatic. Herein, we aimed to report two cases with mesenteric lipoma presenting with abdominal pain and distention who were diagnosed by computed tomography (CT) and magnetic resonance imaging (MRI). Computed tomography and magnetic resonance imaging features of lipomas are characteristic but not always specific. Pathological examination may be necessary to differentiate giant sized lipomas from malignant lesions, and imaging modalities provides great convenience for biopsy interventions. Surgical operation may be essential for symptomatic lipomas.
Keywords: Lipoma, CT, MRI, differential diagnosis, biopsy
A case of hyperamylasemia: Macroamylasemia? Review of the literature
Mehmet Yalnız, Mehmet Asoğlu, Ulvi Demirel, Cem Aygün, İbrahim Halil Bahçecioğlu
J Clin Exp Invest 2011;2(1):98-101.
https://doi.org/10.5799/ahinjs.01.2011.01.0219
Case Report
[Abstract]
[PDF]
ABSTRACT
Amylase is one of the analyzed tests in patients evaluated for abdominal pain. Macroenzyme disorder, a benign condition without any requirement for any treatment is among the reasons of the high serum enzyme levels. Macroamylasemia is the most frequently encountered macroenzyme disorder. Herein, we present a patient with abdominal pain and persistent high amylase levels considered as macroamylasemia. Establishing the diagnosis of macroenzyme disorder as the cause of the unexplained high enzyme levels prevents unnecessary, expensive and even invasive diagnostic and therapeutic procedures.
Keywords: Abdominal pain, hyperamylasemia, macroamylasemia
A rare cause of native tricuspid valve endocarditis: Abortus
Zuhal Arıtürk Atılgan, Faruk Hökenek, Ebru Öntürk Tekbaş, M.Sıddık Evsen, Celal Yavuz
J Clin Exp Invest 2011;2(1):102-105.
https://doi.org/10.5799/ahinjs.01.2011.01.0220
Case Report
[Abstract]
[PDF]
ABSTRACT
A 28-year-old female patient, who at her 7 weeks of pregnancy, admitted to hospital with abdominal pain and vaginal bleeding. She had been hospitalized in another center with the diagnosis of spontaneous complete abortion. After discharge, her clinical process, deteriorated due to fever, chills and fatigue there-fore she had been admitted to emergency unit of that hospital once again, and received non-specific anti-biotics. She was referred to our clinic because of persistant complaints. Transthoracic echocardiography showed vegetations on the tricuspid valve leading to diagnosis of infective endocarditis, so treatment was started at our clinic. No microorganism isolated in blood cultures. Following 15-days antibiotic therapy no reduction was seen in the diameter of the vegetation, therefore surgical operation was planned and a bio-prosthetic tricuspid valve was put into place. In this article we aimed to report the development of sponta-neous abortus at 7 weeks of pregnancy, in order to emphasize that tricuspid valve endocarditis can be developed secondary to very rare causes.
Keywords: Tricuspide valve, endocarditis, abortus, echocardiography
The role of three-dimensional ultrasound in the differential diagnosis of omphalocele and gastroschisis
Kahraman Ülker, İsmail Temur, Mehmet Karaca, İslim Volkan, Mustafa Ersöz, Abdülaziz Gül
J Clin Exp Invest 2011;2(1):106-109.
https://doi.org/10.5799/ahinjs.01.2011.01.0221
Case Report
[Abstract]
[PDF]
ABSTRACT
Gastroschisis and omphalocele are the two of the most common malformations of the anterior abdominal wall that both of them associated with high morbidity and mortality. Sometimes the diagnosis and the realization of the situations by physicians and the parents are difficult. Herein, one omphalocele and one gastroschisis cases were presented with the two-dimensional and three-dimensional ultrasonographic diagnostic features. The two entities and the role of three-dimensional ultrasound in diagnosis and the clinical management of the situations are discussed in the view of medical literature. The three-dimensional ultrasound helps in the diagnosis and detection of the severity of the omphalocele and the gastroschisis.
Keywords: Three-dimensional imaging, omphalocele, gastroschises, birth defects
Association of multiple myeloma and gastric adenocarcinoma
Cengiz Demir, Murat Atmaca, Eyup Tasdemir, Servet Efe
J Clin Exp Invest 2011;2(1):110-113.
https://doi.org/10.5799/ahinjs.01.2011.01.0222
Case Report
[Abstract]
[PDF]
ABSTRACT
Solid tumors associated with multiple myeloma have been demonstrated. However, it is a controversial subject whether there is a risk factor for the development of a secondary tumor. Here we reported a case with multiple myeloma and gastric adenocarcinoma. A 77 years old male patient was admitted with complaints of bone pain, left leg weakness, weight loss and epigastric pain. Patient's examination revealed monoclonal gammopathy, lytic bone lesions and infiltration of plasma cells in bone marrow. Endoscopic examination revealed a mass in the proximal stomach and pathological examination of ulcerated mass showed gastric adenocarcinoma.
Coexistence of these two disease entities needed to be explained by further large-scale researches.
Keywords: Multiple myeloma, gastric adenocarcinoma, coexistence
A case of acute myeloid leukemia presenting with deep venous thrombosis
Mustafa Çalık, İbrahim Etem Pişkin, Gonca Üstündağ, Hakan Kardeş
J Clin Exp Invest 2011;2(1):114-117.
https://doi.org/10.5799/ahinjs.01.2011.01.0223
Case Report
[Abstract]
[PDF]
ABSTRACT
Deep venous thrombosis is mostly associated with an underlying risk factor such as venous catheter, infectious diseases, hereditary thrombophilia and metabolic diseases. Cancer is one of the most common primary disorders in pediatric venous thrombosis, accounting for one-fifth of children with thrombotic events. Here we report a 13-year-old female patient who is diagnosed as deep vein thrombosis due to acute myeloid leukemia.
Keywords: Venous thrombosis, acute myeloid leukemia, children, cancer
Models of experimental epilepsy
Gönül Bambal, Duygu Çakıl, Fatih Ekici
J Clin Exp Invest 2011;2(1):118-123.
https://doi.org/10.5799/ahinjs.01.2011.01.0224
Review
[Abstract]
[PDF]
ABSTRACT
Epilepsy is the most common serious neurological condition in the world, with an estimated prevalence of 1% of the population. A large number of experimental models of seizure and epilepsy have been developed. These experimental models are elicited by chemical convulsants, electrical stimulation, genetic models, structural lesions, physical stimuli (cold, pressure, hyperthermia, electrical) in animals. Well-characterized animal models may allow the understanding of the basic mechanisms underlying epileptogenesis (it refers to the alteration of a normal neuronal network into a hyperexcitable network in which recurrent, spontaneous seizures occur). Moreover, these models might also prove useful in identifying novel therapeutic approaches to treatment of epilepsy.
Keywords: Epilepsy, seizure, experimental models
The relationship between prostate cancer and apoptosis
Funda Kosova, Zeki Arı
J Clin Exp Invest 2011;2(1):124-131.
https://doi.org/10.5799/ahinjs.01.2011.01.0225
Review
[Abstract]
[PDF]
ABSTRACT
Prostate is the largest accessory gland of male genital tract and the beginning part of male urethra. Prostate cancer is the most common internal malignancy in males. Prostate cancer is ranked as second in death from to cancer. A malignant disease is known as uncontrolled proliferation of cells. Beside excessive proliferation, decreased apoptosis was also observed contribute to the development of malignancy. Apoptosis (programmed cell death) plays an important role in many diseases and free radical damage, triggers by cytokines and inflammatory injury. This review has been prepared to show the interesting link between apoptosis and cancer and to provide collective source to who want to do research on this subject.
Keywords: Prostate, cancer, apoptosis