Models of experimental epilepsy
Gönül Bambal 1 * , Duygu Çakıl, Fatih Ekici
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1 Dumlupınar Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, Kütahya, Turkey* Corresponding Author

Abstract

Epilepsy is the most common serious neurological condition in the world, with an estimated prevalence of 1% of the population. A large number of experimental models of seizure and epilepsy have been developed. These experimental models are elicited by chemical convulsants, electrical stimulation, genetic models, structural lesions, physical stimuli (cold, pressure, hyperthermia, electrical) in animals. Well-characterized animal models may allow the understanding of the basic mechanisms underlying epileptogenesis (it refers to the alteration of a normal neuronal network into a hyperexcitable network in which recurrent, spontaneous seizures occur). Moreover, these models might also prove useful in identifying novel therapeutic approaches to treatment of epilepsy.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Review

J Clin Exp Invest, Volume 2, Issue 1, March 2011, 118-123

https://doi.org/10.5799/ahinjs.01.2011.01.0224

Publication date: 11 Mar 2011

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