Labile Hemoglobin - A Biochemical Entity
Rinu Goyal, Vandana Sardana
J Clin Exp Invest 2020;11(1):em00732.
https://doi.org/10.5799/jcei/6340
Case Report
[Abstract]
[PDF]
[References]
ABSTRACT
Diabetes mellitus is a major health disease and may vary in clinical presentation and progression. Although Glucose Fasting and Post prandial levels give a measure of the current plasma glucose level, Glycated haemoglobin is the key analyte used to assess the glycemic control and risk of complications of patients with diabetes. Labile hemoglobin A1c is also known as pre-HbA1c or LA1c or pre-glycohemoglobin. It is an unstable form, (a Schiff base) formed during non-enzymatic glycation of hemoglobin. The concentration of labile fraction varies with acute change in plasma glucose level. Labile hemoglobin may potentially interfere in the estimation of HbA1c and cause a falsely low value and may even hamper or delay the prompt treatment required in diabetics. This calls for a detailed and careful study of chromatograms generated for each sample.
Keywords: glycated hemoglobin, labile hemoglobin, acute changes in plasma glucose, chromatogram
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Vaginal Birth Related Perineal Traumas and the Importance of Experimental Trainings
Hülya Erbaba, Przemyslaw Ciesielski
J Clin Exp Invest 2020;11(1):em00733.
https://doi.org/10.5799/jcei/7589
Research Article
[Abstract]
[PDF]
[References]
ABSTRACT
Perineal trauma caused by vaginal delivery is a problem that can occur in various ways from small lacerations to anal sphincter injury and one that negatively affects the quality of life of the woman. Specialists or midwives liable at perineal trauma repair are required to complete the intervention training for perineal trauma before their clinical practice and increase their skills with in-service training. The most important training materials used in the trainings organized for this purpose are the models consisting of materials that have very close properties to the actual tissues and organs. The aim of this study is to reveal the importance of skills training given to individuals responsible for repairing perineal traumas and to evaluate the effect of different application examples in this field.
Keywords: perineal traumas, experimental trainings, animal and artificial tissue
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Comparison of the Clinical Results of Patients who Underwent PCL-retaining and PCL-substituting Total Knee Arthroplasty
Zekeriya Okan Karaduman
J Clin Exp Invest 2020;11(1):em00734.
https://doi.org/10.5799/jcei/7590
Research Article
[Abstract]
[PDF]
[References]
ABSTRACT
Objective: This study aimed to retrospectively evaluate patients undergoing total knee arthroplasty (TKA) and compare clinical results of patients with posterior cruciate ligament (PCL)-retaining and PCL-substituting TKA.
Method: The clinical results of 60 patients who underwent TKA (30 PCL retaining and 30 PCL substituting) at Düzce University Faculty of Medicine Hospital between September 2014 and September 2016 were evaluated and compared. The clinical results were evaluated using knee scores and knee functional scores according to the American Knee Society Criteria.
Results: The mean postoperative flexion angles were 110.33° ± 5.71° (100°–120°) in the PCL-substituting group and 102.50° ± 5.69° (90°–110°) in the PCL-retaining group, the postoperative knee scores were 90.20 ± 5.16 and 84.07 ± 5.87, respectively, and postoperative knee functional scores were 80.60 ± 7.86 and 78.17 ± 7.25, respectively. Knee scores were significantly different between the groups (P < 0.001). There was no significant difference between the groups in terms of knee functional scores.
Conclusion: Compared with the literature, knee scores of the PCL-substituting group yielded significant results, whereas the knee functional scores were similar to those of the PCL-retaining group. The results reported here indicate that clinical outcomes and survival are not different for either surgical option, and it is possible to achieve good results in both groups when appropriate soft tissue balance is achieved.
Keywords: knee osteoarthritis, posterior cruciate ligament-retaining total knee arthroplasty, posterior cruciate ligament-substituting total knee arthroplasty, total knee arthroplasty
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