A Comparative Analysis of the Effects of Melatonin and Nimodipine on Vasospasm
Ezgi Akar, Kaan Ersegun Batçık, Cengiz Acar, Özlem Ton, Hüseyin Canaz, Serhat Baydın, Osman Akdemir, İbrahim Alataş
J Clin Exp Invest 2018;9(3):113-118.
https://doi.org/10.5799/jcei.458757
Research Article
[Abstract]
[PDF]
[References]
ABSTRACT
Objective: In this study, we aimed to compare the efficacy of nimodipine and melatonin in a rat femoral artery vasospasm model.
Material and Methods: The rats were divided into five groups as follows: Group I (n=8): control group, Group II (n=8): vasospasm group, Group III (n=8): vasospasm + melatonin group, Group IV (n=8): vasospasm + nimodipine group, Group V (n=8 rats): vasospasm + melatonin + nimodipine group. At the end of the 7th day, the femoral arteries were excised and histopathologically examined under light microscope.
Results: Vascular wall of vasospasm group was relatively thicker when compared with the control group. There was a statistically significant difference between the wall thickness of Group II and Group III, IV and V. The maximum reduction of wall thickness was observed in Group V. There was no statistically significant difference in lumen diameter between Group I and Group IV. The lumen diameter was found to be increased in Group III, IV and V when compared with Group II.
Conclusion: The development of experimental peripheral vasospasm has been reduced by the melatonin and nimodipine and their effect was increased when they were used concomitantly.
Keywords: Melatonin, Nimodipine, Cerebral vasospasm, Rat femoral artery, Subarachnoid hemorrhage
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Effects of Home Visits and Planned Education on Mothers’ Postpartum Depression and Quality of Life
Havva Tel, Sukran Ertekin Pinar, Gulseren Daglar
J Clin Exp Invest 2018;9(3):119-125.
https://doi.org/10.5799/jcei.458759
Research Article
[Abstract]
[PDF]
[References]
ABSTRACT
Objective: The present study aims at determining the effects of home visits and planned training on mothers’ postpartum depression and quality of life.
Materials and Methods: The sample of quasi-experimental study was consisted of 70 women. Study data were collected by means of a personal information questionnaire, the Edinburgh Postpartum Depression Scale and the World Health Organization Quality of Life Scale (WHOQOL-BREF).
Results: The average age of the mothers is between 25.50±4.78. In repeated measurements, statistically significant differences were found among quality of life scores of mothers (p<0.05), and their quality of life scores were found to be higher in the third measurement when compared to the first measurement. In all repeated measurements, a statistically significant negative relationship was found between depression and quality of life scores of mothers (p<0.05), and mothers’ depression scores were seen to decrease as their quality of life scores increased. Statistically significant differences (p<0.05) were found among depression scores according to mothers’ education level and among quality of life scores according to their number of pregnancies. University graduate mothers’ depression scores decreased in the second measurement and scores were the same in the third measurement. In the third measurement, primiparous mothers’ quality of life scores were found to be higher than in the first measurement.
Conclusions: The study findings demonstrate that mothers are at risk of depression during the postpartum period, postpartum depression negatively affects their quality of life, and home visits and training increase their quality of life and decrease their depression risk.
Keywords: health education, home visits, postpartum depression, quality of life
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Assessment of Neurological Diagnoses in Patients Applying to the Health Board
Ali Zeynal Abidin Tak, Yusuf Ehi
J Clin Exp Invest 2018;9(3):126-130.
https://doi.org/10.5799/jcei.458760
Research Article
[Abstract]
[PDF]
[References]
ABSTRACT
Objective: This study aims to identify disability rate cases due to neurological diseases obtained from the neurological healthcare board at Adıyaman University Faculty of Medicine.
Patients and Methods: As for participants of the study, the data of the cases applied to the Neurological Health Board of Adıyaman University Faculty of Medicine between January 2017 and December 2017 were evaluated retrospectively. The diagnosis, age, sex, disability rates and interrelationships of the cases were studied. The obtained data was analyzed.
Results: 958 cases were evaluated in total. 469 (49%) of these cases were male and 488 (51%) were female. The mean age of all cases was calculated to be 54.70 ± 28.8 (1-114) years, the mean age of men was lower (p <0.01) than that of women. The most common diagnoses were observed as dementia, epilepsy and cerebrovascular disease.
Conclusion: Determining the data of cases evaluated by the neurology healthcare board will help prevent disability and will contribute to the future studies on disability.
Keywords: Neurology, disability rate, health board
REFERENCES
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Successful management of acute bismuth intoxication complicated with acute renal failure, seizures and acute pancreatitis in a child
Aydın Ece, Zeki Tünay
J Clin Exp Invest 2018;9(3):131-134.
https://doi.org/10.5799/jcei.458761
Brief Report
[Abstract]
[PDF]
[References]
ABSTRACT
Bismuth salts, including bismuth subcitrate, are commonly used for gastrointestinal disorders. Overdose of bismuth salts can lead to renal failure. Seizures and pancreatitis have not been reported as complications of bismuth overdose and/or chelator treatment up-to-date. An 8-year-old girl was presented with history of taking 18 grams of bismuth subcitrate, headache, agitations and anuria. She was hypertensive and her serum creatinine was 6.5 mg/dL with the estimated glomerular filtration rate of 9.61 ml/min/1.73 m2. Antihypertensive drugs and hemodialysis were initiated. Fifteen hemodialysis sessions were performed during a month. At the sixth day of hospitalization dimercaptosuccinic acid (DMSA) treatment was initiated for chelating bismuth. Because of intense headache and seizures were observed after 7 days of DMSA therapy, DMSA was stopped and anticonvulsive drugs were given. Meanwhile pancreatitis was diagnosed based on ultrasound findings and increased serum lipase (maximum, 1363 IU/L) and amylase (maximum, 798 IU/L) levels. Following 10 days of anuria, polyuria developed. Clinical and laboratory findings of her returned to normal at the 35th day of hospitalization. In conclusion, seizures and pancreatitis may develop following chelator treatment for bismuth overdose. Chelation therapy should be used cautiously in bismuth intoxication.
Keywords: Bismuth intoxication, child, chelation therapy, complication, seizure, pancreatitis
REFERENCES
- Cengiz N, Uslu Y, Gök F, Anarat A. Acute renal failure after overdose of colloidal bismuth subcitrate. Pediatr Nephrol. 2005;20:1355-8.
- Slikkerveer A, Noach LA, Tytgat GN, Van der Voet GB, De Wolff FA. Comparison of enhanced elimination of bismuth in humans after treatment with meso-2,3-dimercaptosuccinic acid and D,L-2,3- dimercaptopropane-1-sulfonic acid. Analyst 1998;123:91-2.
- Teepker M, Hamer HM, Knake S, Bandmann O, Oertel WH, Rosenow F. Myoclonic encephalopathy caused by chronic bismuth abuse. Epileptic Disorders. 2002;4:229-33.
Duodenal Perforation by an Ingested Nail
Cihan Bedel, Önder Tomruk, Sadiye Yolcu, Levent Albayrak
J Clin Exp Invest 2018;9(3):135-136.
https://doi.org/10.5799/jcei.458763
Case Report
[Abstract]
[PDF]
[References]
ABSTRACT
Foreign body ingestion is a rare gastrointestinal entity in adults. Foreign bodies generally do not cause any complications and pass through the gastrointestinal tract spontaneously within a week. 10%-20% of them need endoscopic management, and about 1% of them require surgery. In adults, foreign body ingestion can also occur, especially in people with intellectual disabilities, alcoholics, and in those without teeth, but it also can result from accidental swallowing. We present a case of foreign bodies ingestion by a mentally retarded patient with perforation of duodenum.
Keywords: Duodenum perforation, ingested nail, mentally retarded patient, acute abdomen
REFERENCES
- Ozkan Z, Kement M, Kargı AB, Censur Z, Gezen FC, Vural S, et al. An interesting journey of an ingested needle: a case report and review of the literature on extra-abdominal migration of ingested foreign bodies. J Cardiothorac Surg. 2011;6:77.
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- Telford JJ. Management of ingested foreign bodies. Can J Gastroenterol. 2005;19:599-601.
- Velitchkov NG, Grigorov GI, Losanoff JE, et al. Ingested foreign bodies of the gastrointestinal tract: retrospective analysis of 542 cases. World J Surg. 1996;20:1001-5.
- Litovitz T, Schmitz BF. Ingestion of cylindrical and button batteries: an analysis of 2382 cases. Pediatrics. 1992;89:747-57.
- Cebicci H, Alpaslan M. Foreign Bodies Ingested by a Mentally Retarded Turk J Emerg Med. 2015;15:57.
Undetected Duplication Cyst of The Cecum Until Adulthood
Oguzhan Ozsay, Fevzi Cengiz, Nese Ekinci, Salih Can Celik, Kemal Erdinc Kamer
J Clin Exp Invest 2018;9(3):137-139.
https://doi.org/10.5799/jcei.458764
Case Report
[Abstract]
[PDF]
[References]
ABSTRACT
Intestinal duplication is a rare congenital anomaly of the digestive tract. It is often diagnosed antenatally or in the first two years of life. It is observed anywhere in the digestive tract, often in ileum and jejunum. We present a rare case of colonic duplication cyst in adult age in this paper. Our case was diagnosed by ultrasonography performed due to the complaint of chronic abdominal pain and was followed up for 18 months. The patient underwent surgery due to strong suspicion of malignancy. During the operation, the cyst was accessed only after palpation and was resected together with the right colon. The definitive diagnosis could be made by pathological examination. Duplication cysts can cause significant morbidity and even mortality if left untreated. For this reason, it is important to recognize this rare congenital anomaly.
Keywords: Colonic duplication, gastrointestinal congenital anomaly, adult
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