A Comparative Analysis of the Effects of Melatonin and Nimodipine on Vasospasm
Ezgi Akar 1 * , Kaan Ersegun Batçık 2, Cengiz Acar 2, Özlem Ton 3, Hüseyin Canaz 2, Serhat Baydın 2, Osman Akdemir 2, İbrahim Alataş 2
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1 Haydarpaşa Numune Training and Research Hospital, Neurosurgery Department, Istanbul, Turkey2 Haseki Training and Research Hospital, Neurosurgery Department, Istanbul, Turkey3 Şişli Hamidiye Etfal Training and Research Hospital, Pathology Department, Istanbul, Turkey* Corresponding Author

Abstract

Objective: In this study, we aimed to compare the efficacy of nimodipine and melatonin in a rat femoral artery vasospasm model.
Material and Methods: The rats were divided into five groups as follows: Group I (n=8): control group, Group II (n=8): vasospasm group, Group III (n=8): vasospasm + melatonin group, Group IV (n=8): vasospasm + nimodipine group, Group V (n=8 rats): vasospasm + melatonin + nimodipine group. At the end of the 7th day, the femoral arteries were excised and histopathologically examined under light microscope.
Results: Vascular wall of vasospasm group was relatively thicker when compared with the control group. There was a statistically significant difference between the wall thickness of Group II and Group III, IV and V. The maximum reduction of wall thickness was observed in Group V. There was no statistically significant difference in lumen diameter between Group I and Group IV. The lumen diameter was found to be increased in Group III, IV and V when compared with Group II.
Conclusion: The development of experimental peripheral vasospasm has been reduced by the melatonin and nimodipine and their effect was increased when they were used concomitantly.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, Volume 9, Issue 3, September 2018, 113-118

https://doi.org/10.5799/jcei.458757

Publication date: 23 Sep 2018

Article Views: 2688

Article Downloads: 1667

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