Abstract
Objective: To understand the relationship among affective disorders and hormonal and biochemical parameters in women with polycystic ovary syndrome (PCOS).
Methods: Women with PCOS (n=15) were compared to body mass index and age matched control group (n=19). Beck Depression Inventory and Stait Trait Anxiety Inventory were used to assess the presence of depression and anxiety symptoms.
Results: Depression and anxiety scores of women with PCOS correlated with free testosterone levels. Their anxiety scores correlated with HDL and lipoprotein-a (Lp-a), an independent marker for increased cardiovascular disease. In the control group anxiety score correlated with interleukin-1β.
Conclusion: There was a relationship between increased androgens and affective disorders in women with PCOS. The correlation between Lp-a and anxiety scores may be the link between affective disorders and cardiovascular diseases. A different mechanism may play role in the pathophysiology of affective disorders in women with PCOS.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Article Type: Research Article
J Clin Exp Invest, Volume 4, Issue 1, March 2013, 13-19
https://doi.org/10.5799/ahinjs.01.2013.01.0227
Publication date: 14 Mar 2013
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