Objective: To understand the relationship among affective disorders and hormonal and biochemical parameters in women with polycystic ovary syndrome (PCOS).
Methods: Women with PCOS (n=15) were compared to body mass index and age matched control group (n=19). Beck Depression Inventory and Stait Trait Anxiety Inventory were used to assess the presence of depression and anxiety symptoms.
Results: Depression and anxiety scores of women with PCOS correlated with free testosterone levels. Their anxiety scores correlated with HDL and lipoprotein-a (Lp-a), an independent marker for increased cardiovascular disease. In the control group anxiety score correlated with interleukin-1β.
Conclusion: There was a relationship between increased androgens and affective disorders in women with PCOS. The correlation between Lp-a and anxiety scores may be the link between affective disorders and cardiovascular diseases. A different mechanism may play role in the pathophysiology of affective disorders in women with PCOS.