The relationship between affective disorders and hormonal and metabolic parameters in women with polycystic ovary syndrome
Nilgün Güdücü 1 * , Uzay Görmüş, Başak Özge Kayan, Zehra Neşe Kavak, İlkkan Dünder
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1 İstanbul Bilim Unıversity, Avrupa Hospital, Dept. Obstetrics&Gynecology, İstanbul, Turkey* Corresponding Author


Objective: To understand the relationship among affec­tive disorders and hormonal and biochemical parameters in women with polycystic ovary syndrome (PCOS).
Methods: Women with PCOS (n=15) were compared to body mass index and age matched control group (n=19). Beck Depression Inventory and Stait Trait Anxiety Inven­tory were used to assess the presence of depression and anxiety symptoms.
Results: Depression and anxiety scores of women with PCOS correlated with free testosterone levels. Their anxi­ety scores correlated with HDL and lipoprotein-a (Lp-a), an independent marker for increased cardiovascular dis­ease. In the control group anxiety score correlated with interleukin-1β.
Conclusion: There was a relationship between increased androgens and affective disorders in women with PCOS. The correlation between Lp-a and anxiety scores may be the link between affective disorders and cardiovas­cular diseases. A different mechanism may play role in the pathophysiology of affective disorders in women with PCOS.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2013, Volume 4, Issue 1, 13-19

Publication date: 14 Mar 2013

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Article Downloads: 784

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