Objectives: The purpose of this randomized study is to compare the effects of esmolol and lidocaine in the control of hemodynamic response caused by endotracheal intubation.
Methods: In this study, 40 patients with ASA I-II physical status and between the ages of 19 and 76 were included and randomly divided into two groups. In the Group E (n = 20), iv bolus injection of 1.5 mg/kg esmolol, in the Group L (n = 20), iv bolus injection of 1.5 mg/kg 2% lidocaine were given with iv bolus injection in 30 seconds. All patients received the same anesthetic technique. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP) and heart rate measurements were done at specified times and recorded. Records were assessed by an anesthesiologist blinded to which drug is applied.
Results: There was no difference between the groups in demographic data (p>0.05). In both groups, with the implementation of the study drug, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure decreased compared to controls, this reduction was lower in Group E than Group L. In Group L, SBP values of 1.5 and 7 minutes were higher than Group E (p <0.05). In Group L, DBP and MBP values of 1.5 and 3.5 minutes were higher than Group E (p <0.05).
Conclusion: In conclusion, 1.5 mg/kg esmolol or 1.5 mg/ kg lidocaine administered prior to induction were not superior to each other regarding suppression of hemodynamic responses to intubation.