Comparison of the efficacy of esmolol and lidocaine in the control of hemodynamic response associated with intubation: A randomized controlled trial
Tolga Ergönenç 1 * , Jalan Şerbetçigil, Uğur Uzun, Ali Dirik, Gülşen Bican
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1 Education and Research Hospital, Dept. Anesthesiology&Reanimation, Sakarya, Turkey* Corresponding Author


Objectives: The purpose of this randomized study is to compare the effects of esmolol and lidocaine in the con­trol of hemodynamic response caused by endotracheal intubation.
Methods: In this study, 40 patients with ASA I-II physical status and between the ages of 19 and 76 were included and randomly divided into two groups. In the Group E (n = 20), iv bolus injection of 1.5 mg/kg esmolol, in the Group L (n = 20), iv bolus injection of 1.5 mg/kg 2% lidocaine were given with iv bolus injection in 30 seconds. All pa­tients received the same anesthetic technique. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP) and heart rate measure­ments were done at specified times and recorded. Re­cords were assessed by an anesthesiologist blinded to which drug is applied.
Results: There was no difference between the groups in demographic data (p>0.05). In both groups, with the implementation of the study drug, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure decreased compared to controls, this reduction was lower in Group E than Group L. In Group L, SBP values of 1.5 and 7 minutes were higher than Group E (p <0.05). In Group L, DBP and MBP values of 1.5 and 3.5 minutes were higher than Group E (p <0.05).
Conclusion: In conclusion, 1.5 mg/kg esmolol or 1.5 mg/ kg lidocaine administered prior to induction were not su­perior to each other regarding suppression of hemody­namic responses to intubation.


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Article Type: Research Article

J Clin Exp Invest, 2013, Volume 4, Issue 1, 20-27

Publication date: 14 Mar 2013

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Article Downloads: 735

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