Comparison of plasma homocysteine levels in patients with type 2 diabetes mellitus with normal subjects
İsmail Erşan 1 * , Banu Turgut Öztürk, Ümit Kamış, Ahmet Özkağnıcı, Kemal Gündüz
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1 Aksaray Devlet Hastanesi, Göz Hastalıkları Kliniği, Aksaray, Turkey
* Corresponding Author

Abstract

Objectives: To compare the plasma homocysteine levels between control group and diabetic patients with no diabetic retinopathy, with preproliferative diabetic retinopathy, with proliferative diabetic retinopathy.
Materials and methods: Plasma homocysteine levels of 23 diabetic patients were measured and were compared with 25 age-matched controls with no systemic problem and no ocular disease. Plasma homocysteine levels were measured using high-performance liquid chromatography.
Results: Diabetic patients were divided into three groups according to their ophthalmological findings. There were 8 patients with no diabetic retinopathy, 8 patients with preproliferative diabetic retinopathy, 7 patients with proliferative diabetic retinopathy. Plasma homocysteine levels were higher in diabetic patients (13.30±4.03 µmol/L) compared to the control group (11.71±3.41 µmol/L) but no statistically significant difference was found between the two groups (p>0.05). Plasma homocysteine levels were measured 12.50±3.73 µmol/L in no diabetic retinopathy group, 12.90±2.59 µmol/L in preproliferative diabetic retinopathy group, 14.64±5.69 µmol/L in proliferative diabetic retinopathy group. In diabetic group, plasma homocysteine levels increased with the increase of the severity of retinopathy but not reached statistically significance (p>0.05).
Conclusion: Although no statistically significance was found, retinopathy progresses with the increase of plasma homocysteine levels. This can be used for the follow-up of the diabetic patients but further evaluation in large groups is needed.

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

https://doi.org/10.5799/ahinjs.01.2012.02.0150

J Clin Exp Invest, 2012 - Volume 3 Issue 2, pp. 235-239

Publication date: 12 Jun 2012

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Article Downloads: 673

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