Relationship among Gensini score and levels of glucose and adiponectin in patients with stable angina pectoris
Ferhat Özyurtlu, Özgül Yıldız, Erkan Ayhan 1 * , Turgay Işık, Halit Acet, Zihni Bilik, Uğur Kemal Tezcan
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1 Diyarbakır Devlet Hastanesi, Kardiyoloji Kliniği, Diyarbakır, Turkey
* Corresponding Author

Abstract

Objectives: Adiponectin is an adipocyte-secreted protein that modulates insulin sensitivity and whose low circulating concentration is associated with insulin resistance. We evaluated the association between serum adiponectin and blood glucose levels with coronary artery disease severity on the angiogram in patients with stable angina pectoris.
Materials and methods: The study included 160 patients (82 males) with stable angina pectoris. The patients were divided into three groups according to the blood glucose levels on admission; thus, 24 had normal glucose group, 53 had impaired glucose tolerance group, and 53 had diabetes mellitus (DM) group. The severity of coronary lesions was assessed using the Gensini score. Serum adiponectin levels were measured in the all group.
Results: The hypertension, hyperlipidemia, obesity, and insulin resistance were significantly higher in the DM group. Patients with DM significantly lower serum levels of adiponectin (13.55±7.16, p=0.002). The mean Gensini score was 40.84± 37.25 in the DM group (p=0.006).
Conclusion: Serum adiponectin levels may be a clue for severity coronary artery disease in patients with stable angina pectoris.

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

https://doi.org/10.5799/ahinjs.01.2012.02.0149

J Clin Exp Invest, 2012 - Volume 3 Issue 2, pp. 229-234

Publication date: 12 Jun 2012

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Article Downloads: 764

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