Effects of Exercise Training With Proprioceptive Equipment on Proprioceptive and Functional Status of Children with Obstetrical Brachial Plexus Injury
Deran Oskay, Edibe Ünal, Gürsel Leblebicioğlu, Zeynep Tuna
J Clin Exp Invest 2017;8(1):1-5.
https://doi.org/10.5799/jcei.328708
Research Article
[Abstract]
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ABSTRACT
Objectives: Decreased proprioception in Obstetric Brachial Plexus Injury (OBPI) reduces the quality of functional movement. Hence, the aim of our study was to evaluate the effects of exercise training with additional proprioceptive equipments on the functional status and proprioceptive sense in children with OBPI.
Materials and Methods: Forty children with OBPI were randomly divided into two groups. Passive, active and active-assisted range of motion and stretching exercises were included in home-based program (HP) group while additional exercises with proprioceptive equipments were also added in the proprioceptive training (PT) group. After 6 weeks, proprioceptive perception and functional level were compared to pre-treatment results.
Results: Proprioceptive perception at the beginning and at the end of the movement increased in both groups (p<0,05). The Active Movement Scale (AMS) scores increased significantly only in some movements in both groups (p<0,05). AMS scores of shoulder abduction and external rotation in PT group were better than HP group (p<0,05).
Conclusions: Home exercise program and proprioceptive exercise training both improve proprioceptive sense and functional status in children with OBPI. The proprioceptive exercise training seems to be more beneficial in improving functional movements of shoulder.
Keywords: Exercise training, obstetrical brachial plexus injuries, proprioception
Evaluation of Protein C Gene Polymorphism in Patients with Pulmonary Embolism
Tuba Ceviz, Nevin Karakuş, Nursah Basol, Serbulent Yigit
J Clin Exp Invest 2017;8(1):6-11.
https://doi.org/10.5799/jcei.328742
Research Article
[Abstract]
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ABSTRACT
Objective: Pulmonary embolism is usually a complication of deep vein thrombosis (DVT) and develops as a result of obstruction of pulmonary artery and/or branches with pieces that ruptured from the DVT of the leg. Pulmonary embolism and DVT is also referred as venous thrombo-embolism (VTE), because two events often remain together. In the studies,
it was found that protein C (PROC) deficiency is a risk factor for pulmonary embolism. In this study, we aimed to evaluate the association between pulmonary embolism and PROC gene -1654C>T polymorphism in Turkish population.
Methods: The DNAs of 114 pulmonary embolism cases and 120 healthy controls have been analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) to evaluate the relation between PROC gene -1654C>T polymorphism and pulmonary embolism in our study. Statistical analyses were performed by using chisquare
and analysis of variance tests.
Results: The proportion of individuals with CT genotype carrying polymorphic T allele as heterozygous form was 38.7% in the control group and 21.9% in the pulmonary embolism cases (p=0.047). When demographic and clinical characteristics of cases compared with PROC gene -1654C>T polymorphism, it was observed that the changes in chest CT ratios could be associated with -1654C>T polymorphism (p=0.017).
Conclusion: As a result, individuals with CT genotypes carrying the polymorphic T allele as heterozygous form have a lower risk of developing pulmonary embolism.
Keywords: PROC, VTE, pulmonary embolism, polymorphism
Inadequate Nutritional Status of Hospitalized Cancer Patients
Ali Alkan, Dılşa Mızrak, Filiz Çay Şenler, Güngör Utkan
J Clin Exp Invest 2017;8(1):12-17.
https://doi.org/10.5799/jcei.328744
Research Article
[Abstract]
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ABSTRACT
Objective: In oncology practice, nutrition and also metabolic activity are essential to support the nutritional status and prevent malignant cachexia. It is important to evaluate the patients and plan the maneuvers at the start of the therapy. The primary objective of the study is to define the nutritional status of hospitalized patients and the factors affecting it in order to define the most susceptible patients and maneuvers for better nutritional support.
Methods: Patients hospitalized in oncology clinic for therapy were evaluated for food intake and nutritional status through structured interviews. The clinical properties, medical therapies, elements of nutritional support were noted and predictors of inadequate nutritional status (INS) were analyzed.
Results: Four hundred twenty three patients, between 16-82 years old (median: 52) were evaluated. Nearly half of the patients (185, 43%) reported a better appetite at home than in hospital and declared that hospitalization is an important cause of loss of appetite (140/185, 75.6%). Presence of nausea/vomiting (N/V), depression, age less than 65 and use of non-steroidal anti-inflammatory drugs (NSAIDs) were associated with increased risk of INS in hospitalized cancer patients. On the contrary, steroid medication showed a positive impact on nutritional status of cancer patients.
Conclusion: N/V, younger age, presence of depression and NSAIDs medication were associated with INS in hospitalized cancer patients. Clinicians should pay more attention to this group of patients. In addition, unnecessary hospitalizations and medications that may disturb oral intake must be avoided. Corticosteroids are important tools for managing anorexia and INS.
Keywords: Inadequate nutritional status, malnutrition, cancer cachexia
Total Phenolic Content, Antioxidant and Cyto-/Genotoxic Activities of Pelargonium Quercetorum Agnew in Human Breast Cancer Cells
Ferda Arı, Serap Celikler, Didem Karakas, Buse Cevatemre, Mehmet Fırat, Engin Ulukaya
J Clin Exp Invest 2017;8(1):18-24.
https://doi.org/10.5799/jcei.328748
Research Article
[Abstract]
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ABSTRACT
Objective: Because the current cancer treatment success rate is not sufficient, plants have been gaining importance as a possible source for anti-cancer compounds. This study aimed to investigate both the genotoxic and cytotoxic activities of methanol extracts of Pelargonium quercetorum Agnew (P. quercetorum), which is traditionally used for its
antihelminthic activity, but has not yet been studied for its effect in breast cancer cells.
Methods: In this study, the cyto-genotoxic activities of methanol extracts of Pelargonium quercetorum were investigated in human breast cancer cells (MCF-7 and MDA-MB-231). The cytotoxic effect of the extract on these cells was evaluated by MTT and ATP viability assays. The mode of cell death (apoptosis/necrosis) was determined using luorescence microscopy and biochemical methods. Genotoxic activity was studied with Comet assay. In addition, the
total phenolic content and antioxidant capacity were determined by the Folin-Ciocalteu and ABTS [2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)] methods, respectively.
Results: Results of this study reveal that Pelargonium quercetorum has a large total phenolic content and high antioxidant capacity. Pelargonium quercetorum induced anti-growth effects in a dose-dependent manner in cancer cells. The extract killed the cells by apoptosis as evidenced by the presence of pyknotic nucleus and annexin V-FITC positivity. The extract also exerted genotoxic activity at relatively low doses.
Conclusion: These results suggest that Pelargonium quercetorum induces apoptosis-like cell death by causing DNA ells.
Keywords: Pelargonium quercetorum, apoptosis, breast cancer cells, DNA damage
Use of Kinesio-Taping in the Management of Hallux Rigidus: A Case Report
Gul Oznur Karabicak, Zeynep Hazar Kanik, Sevgi Sarpel
J Clin Exp Invest 2017;8(1):25-27.
https://doi.org/10.5799/jcei.328750
Case Report
[Abstract]
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ABSTRACT
Hallux rigidus is a progressive degenerative disease of the first metatarsophalangeal joint. It is characterized by pain, limitation of the metatarsophalangeal joint motion, mainly dorsiflexion, progressive osteophyte formation and functional impairment. Although, there have been many studies concerning non-operative management of hallux rigidus, no research has yet examined the effects of kinesio-taping in hallux rigidus. We present a 57-year-old woman with pain and stiffness around the big toe while walking, and functional insufficiency. The patient received kinesio-taping
combined with therapeutic exercise. Pain intensity, range of motion (ROM), functional status were used as the outcome measures. According to the results, kinesio-taping may help reduce pain, increase range of motion and functional levels in patients with hallux rigidus.
Keywords: Hallux rigidus, kinesio-taping, pain, function
CD3 Positive Gastric Plasmablastic Lymphoma in A HIV Negative Patient: A Case Report
Betül Bolat Küçükzeybek, Aylin Orgen Calli, Mehmet Ali Uyaroğlu, Ayşegül Akder Sarı, Ayşe Vatansever, Füsun Özdemirkıran, Bahriye Payzın
J Clin Exp Invest 2017;8(1):28-30.
https://doi.org/10.5799/jcei.328751
Case Report
[Abstract]
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ABSTRACT
Plasmablastic lymphoma is a rare and aggressive lymphoma characterized by the diffuse proliferation of large neoplastic cells resembling immunoblasts with an immunophenotype of plasma cells. A 47-year-old male was referred to our hospital with gastrointestinal bleeding, and a mass 10 cm in diameter, was detected. An endoscopic biopsy was performed subsequently. Histopathological examination of the biopsy material revealed ulcer, alterations associated with ulcer, and further presented a diffuse infiltration of atypical cells with abundant cytoplasm and pleomorphic nuclei, some with crush artifacts in lamina propria. Immunohistochemically, the tumor cells were negative for cytokeratin, CD2, CD20, and PAX5; but they were positive for CD3, MUM1, CD38 and CD138. Ki67 proliferation index was as high as 95%. The case was signed out as CD3-positive plasmablastic lymphoma with clinical, histopathological and immunohisto-chemical findings. The plasmablastic lymphoma case with an aberrant CD3 expression has been
presented here, which is rarely observed in stomach.
Keywords: Plasmablastic lymphoma, CD3, gastric lymphoma