CD3 Positive Gastric Plasmablastic Lymphoma in A HIV Negative Patient: A Case Report
Betül Bolat Küçükzeybek, Aylin Orgen Calli, Mehmet Ali Uyaroğlu, Ayşegül Akder Sarı, Ayşe Vatansever, Füsun Özdemirkıran, Bahriye Payzın
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Abstract

Plasmablastic lymphoma is a rare and aggressive lymphoma characterized by the diffuse proliferation of large neoplastic cells resembling immunoblasts with an immunophenotype of plasma cells. A 47-year-old male was referred to our hospital with gastrointestinal bleeding, and a mass 10 cm in diameter, was detected. An endoscopic biopsy was performed subsequently. Histopathological examination of the biopsy material revealed ulcer, alterations associated with ulcer, and further presented a diffuse infiltration of atypical cells with abundant cytoplasm and pleomorphic nuclei, some with crush artifacts in lamina propria. Immunohistochemically, the tumor cells were negative for cytokeratin, CD2, CD20, and PAX5; but they were positive for CD3, MUM1, CD38 and CD138. Ki67 proliferation index was as high as 95%. The case was signed out as CD3-positive plasmablastic lymphoma with clinical, histopathological and immunohisto-chemical findings. The plasmablastic lymphoma case with an aberrant CD3 expression has been presented here, which is rarely observed in stomach.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Case Report

https://doi.org/10.5799/jcei.328751

J Clin Exp Invest, 2017 - Volume 8 Issue 1, pp. 28-30

Publication date: 31 Mar 2017

Article Views: 1018

Article Downloads: 347

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