Thrombophilic risk factors in women with recurrent abortion
Osman Yokuş, Özlem Şahin Balçık 1 * , Murat Albayrak, Funda Ceran, Mesude Yılmaz, Simten Dağdaş, Gülsüm Özet
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1 Fatih University Medical School Department of Hematology, Ankara, Turkey
* Corresponding Author

Abstract

Objectives: The aim of this study was to determine the thrombophilic risk factors and their frequency among women with history of recurrent abortion and a detected thrombophilic defect.
Materials and methods: In this study, 41 women with history of recurrent abortion, who have one or more detected thrombophilic defects including protein S, protein C, antithrombin deficiency, activated protein C resistance (APC-R), factor V Leiden (FVL), prothrombin G 20210A (PTG), methylenetetrahydrofolate reductase (MTHFR) C677 T gene mutation, antiphospholipid antibodies and elevated levels of factor VIII were retrospectively investigated.
Results: The most common detected thrombophilia defect (53.7%) was MTHFR gene mutation. While 22 of 41 patients (53.7%) had more than one concomitant defect, 20 of them had two concomitant defects and the remaining had three defects.
Conclusion: MTHFR gene mutation, alone and/or with, concurrent thrombophilic defects was the most frequent factor for hereditary thrombophilia among our patients with a history of recurrent abortion.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

https://doi.org/10.5799/ahinjs.01.2010.03.0035

J Clin Exp Invest, 2010 - Volume 1 Issue 3, pp. 168-172

Publication date: 17 Dec 2010

Article Views: 1737

Article Downloads: 566

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