Thrombophilia in complicated pregnancies
Ayşe Şahin 1 * , Mahmut Nedim Çiçek
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1 Diyarbakır Kadın Doğum ve Çocuk Hast., Kadın Hast. ve Doğum Klin, Diyarbakır, Turkey* Corresponding Author


Objective: To investigate the incidence and etiology of pregnancy complications associated with thrombophilic factors.
Methods: Fifty-four patients with complicated pregnancy and 40 healthy pregnant subjects were included the study. Factor V Leiden (FVL) mutation, protein S, protein C, anti-thrombin deficiency levels were investigated.
Results: Of the 54 patients with complicated pregnancy, 29 had preeclampsia, 18 had intra uterine growth retardation, and 7 had intrauterine fetal loss. The most common defect was FVL mutation. FVL mutations in patient group and the control group were 27.2% and 10%, respectively, which were statistically significant. The protein S, protein C, and anti-thrombin deficiencies were found higher in the patient group compared to control (p>0.05 for each).
Conclusion: FVL mutation was found higher in patient group compared to the control group, Protein C deficiency and anti-thrombin deficiency were related to preeclampsia but not other pregnancy complications. Clinicians should take into account the thrombophilia in complicated pregnancy, especially preeclampsia.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2013, Volume 4, Issue 4, 497-502

Publication date: 14 Dec 2013

Article Views: 1828

Article Downloads: 1078

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