The relationship between level of anti-CCP, clinical activity and quality of life in patients with psoriatic arthritis
Remziye Akçalı, Mehtap Bozkurt 1 * , Kemal Nas, İbrahim Yardımeden, Demet Uçar
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1 Dicle Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon A.D. Diyarbakır, Turkey* Corresponding Author


Objectives: Psoriatic arthritis (PsA) is an inflammatory joint disease. The aim of this study was to investigate the titers of Anti-syclic citrullinated protein (anti-CCP antibodies) in PsA and assess their associations with clinical characteristics and quality of life.
Materials and methods: Fourty two patients with PsA and 38 healthy control subjects were included. Demographic data and clinical characteristics including age, gender, disease duration, and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anti-CCP antibodies and rheumatoid factor were assessed. Visual analog scale (VAS), Nottingham Health Profile (NHP) and short form-36 (SF-36) were used to evaluate QOL in both groups.
Results: The demographic data of the subjects were not different between the groups. Patients with PsA had higher anti-CCP levels compared to healthy controls (56.3±73.0 U vs. 0.9±0.5 U, respectively, p=0.01) Thirteen (33.3%) patients with PsA had positive anti-CCP, while no anti-CCP positivity was found in the control group (p<0.001). The scores of NHP social isolation, emotional reaction and pain subscales were significantly higher in PsA patients than in control subjects (p<0.05). The scores of physical domains of NHP were not statistically different between groups. There was no statistically significant correlation between the NHP or the SF-36 scores with ESR or CRP levels in PsA group. SF-36 and NHP were found to be significantly correlated with VAS and fatigue (p<0.05).
Conclusion: Anti-CCP antibody positivity was significantly higher in patients with PsA and anti-CCP titers were not related to quality of life measures.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2011, Volume 2, Issue 2, 187-191

Publication date: 14 Jun 2011

Article Views: 2460

Article Downloads: 1522

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