The impact of obesity on clinical, metabolic and hormonal features in patients with polycystic ovary syndrome
Serap Baydur Şahin 1 * , Fatih Sümer, Hacer Sezgin, Teslime Ayaz, Osman Zikrullah Şahin, Kadir İlkkılıç, Emine Uslu Gür, Ekrem Algün
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1 Recep Tayyip Erdoğan Üniversitesi Eğitim ve Araştırma Hastanesi, Rize, Turkey
* Corresponding Author

Abstract

Objectives: Our aim was to compare the clinical, hormonal and metabolic features between overweight and obese patients with PCOS and normal weight women with polycystic ovary syndrome (PCOS).
Methods: 119 patients with PCOS (15-39 years) were included in the study. We evaluated anthropometric, hormonal and metabolic parameters in all patients.
Results: Ferriman- Gallwey hirsutism score was similar in overweight or obese patients with PCOS (n=78) and normal weight patients with PCOS (n=41) (p=0.373). While 71.8% of the obese group had irregular menses, this ratio was 60.9% in normal weight group (p=0.160). HOMA-IR values were higher in the obese group (1.7±0.7 vs 3.3±1.7, p<0.001). Serum triglyceride (87.2±49.8 vs. 123.4±65.3 mg/dl) and LDL-cholesterol levels (104.5±29.4 vs 121.7±32.9 mg/dl) were higher in obese group than the normal weight group (p=0.002, p=0.006). HDL-cholesterol levels were lower in obese group (46.5±11 vs 56.7±11.7 mg/dl, p<0.001). Free testosterone levels were 3.54±2.5 pg/ml in overweight and obese group and 2.36 ± 1.2 pg/ml in normal weight group (p = 0.016). While BMI was positively correlated with age (r=0.210), waist circumference (r=0.916), systolic (r=0.238) and diastolic blood pressure (r=0.181), insulin (r=0.635), HOMA-IR (r=0.650), total-C ( r=0.242), LDL-C (r=0.295), triglyceride (r=0.424) and total testosterone (r=0.230), it was negatively correlated with HDL-C (r=-0.476).
Conclusion: Obesity did not influence hirsutism and menstruel regularity in patients with PCOS in this study, however obesity deteriorated insulin sensitivity and lipid profile.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

https://doi.org/10.5799/ahinjs.01.2014.04.0459

J Clin Exp Invest, 2014 - Volume 5 Issue 4, pp. 567-571

Publication date: 10 Dec 2014

Article Views: 1321

Article Downloads: 471

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