Relationship between adiponectin and adiponectin receptor 1 gene polymorphisms with colorectal cancer
Badel Arslan Mamur 1 * , Etem Akbaş, Tahsin Çolak, Mehmet Özgür Türkmenoğlu, Hakan Seyit, Mehmet Ali Sungur
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1 Mersin Üniversitesi Tıp Fakültesi Tıbbi Biyoloji AD, Mersin, Turkey
* Corresponding Author

Abstract

Objectives: Adiponectin is a protein synthesized from adipose tissue and it is also an endogeneous insulin sensitizer. Adiponectin seems to act in preneoplastic colonic lesions to regulate cell growth by activating, altering, or interacting with several pathways including the leptin and the NFkB pathways. This study aims to investigate the relationship of T/G rs2241766ADIPOQ exon 2 (+45,codon 15) and A/G rs2275738ADIPOR1 intron 1 (-106) polymorphisms with CRC risk.
Methods: The studying group consist of total 266 person which 129 of them are colorectal cancer cases who were diagnosed at the Mersin University Medical Faculty Hospital and 137 controls participating. Genotypes were determined using PCR/RFLP methods.
Results: It was found that there is no relationship between T/G rs2241766ADIPOQ exon 2 (+45, codon 15) and A/G rs2275738ADIPOR1 intron 1 (-106) polymorphisms and the risk of developing colorectal cancer. It was determined an increasing risk of colorectal cancer with male subjects and old age groups.
Conclusion: In conclusion, it was found that rs2241766 and rs2275738 polymorphisms may not be related to the progression of colorectal cancer.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

https://doi.org/10.5799/ahinjs.01.2014.04.0460

J Clin Exp Invest, 2014 - Volume 5 Issue 4, pp. 572-576

Publication date: 10 Dec 2014

Article Views: 1486

Article Downloads: 527

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