The expression of Fetuin-A in brain tissues of WAG/Rij Rats, genetic rat model of absence epilepsy
Ramazan Yüksel 1 * , Gönül Gürol, Zeynep Seçkin Akkılık, Sibel Sarı, Sevil Arabacı, Didem Güneri, Kadir Demircan, Fatih Ekici
More Detail
1 Yıldırım Beyazıt Üniversitesi Tıp Fakültesi, Fizyoloji AD, Bilkent, Ankara, Turkey
* Corresponding Author

Abstract

Objective: In the present study, we aimed to determine the Fetuin-A levels in different regions of the brain in absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats in order to contribute the identification of new potential biomarkers of the diagnosis, prognosis and follow up the epilepsy treatment.
Methods: 1, 3 and 6 months old male WAG/Rij rats (n=21) with absence epilepsy were used in this study. All of the rats were decapitated under anesthesia and their cortex and thalamus tissues were isolated. Fetuin-A levels of the groups were determined by Western Blot method by using standard techniques and differences between densities of the groups were compared.
Results: According to data obtained, there was no Fetuin-A expression in brain cortex and thalamus tissues of WAG/Rij rats with absence epilepsy.
Conclusion: In this study, it was shown that Fetuin-A is not expressed in brain cortex and thalamus tissues of WAG/Rij rats with absence epilepsy throughout the age-related development. By evaluating the findings obtained, extensive researches that contain molecular and histological methods must be planned, Fetuin-A findings that are obtained experimentally must be confirmed.

License

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

https://doi.org/10.5799/ahinjs.01.2015.04.0554

J Clin Exp Invest, 2015 - Volume 6 Issue 4, pp. 387-390

Publication date: 03 Jan 2016

Article Views: 1469

Article Downloads: 509

Open Access References How to cite this article