The expression of Fetuin-A in brain tissues of WAG/Rij Rats, genetic rat model of absence epilepsy
Ramazan Yüksel 1 * , Gönül Gürol, Zeynep Seçkin Akkılık, Sibel Sarı, Sevil Arabacı, Didem Güneri, Kadir Demircan, Fatih Ekici
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1 Yıldırım Beyazıt Üniversitesi Tıp Fakültesi, Fizyoloji AD, Bilkent, Ankara, Turkey* Corresponding Author


Objective: In the present study, we aimed to determine the Fetuin-A levels in different regions of the brain in absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats in order to contribute the identification of new potential biomarkers of the diagnosis, prognosis and follow up the epilepsy treatment.
Methods: 1, 3 and 6 months old male WAG/Rij rats (n=21) with absence epilepsy were used in this study. All of the rats were decapitated under anesthesia and their cortex and thalamus tissues were isolated. Fetuin-A levels of the groups were determined by Western Blot method by using standard techniques and differences between densities of the groups were compared.
Results: According to data obtained, there was no Fetuin-A expression in brain cortex and thalamus tissues of WAG/Rij rats with absence epilepsy.
Conclusion: In this study, it was shown that Fetuin-A is not expressed in brain cortex and thalamus tissues of WAG/Rij rats with absence epilepsy throughout the age-related development. By evaluating the findings obtained, extensive researches that contain molecular and histological methods must be planned, Fetuin-A findings that are obtained experimentally must be confirmed.


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Article Type: Research Article

J Clin Exp Invest, 2015, Volume 6, Issue 4, 387-390

Publication date: 03 Jan 2016

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Article Downloads: 1077

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