The Effect of Elevated Homocysteine Levels on Atherosclerosis in Patients with Peritoneal Dialysis
Fatih Şahpaz 1 *
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1 Dumlupınar Üniversitesi iç hastalıkları AD, Kütahya, Turkey* Corresponding Author


Objective: Cardiovascular disease is an important cause of morbidity and mortality in patients with renal failure. Pa­tients with chronic renal failure are significantly suscep­tible to atherosclerosis. In the present study, we aimed to investigate the effect of elevated homocysteine on ath­erosclerosis and inflammation in continuos ambulatory peritoneal dialysis (CAPD) patients.
Methods: 56 patients undergoing CAPD and 27 healthy subjects was enrolled in the study. All patients total cho­lesterol, triglyceride, LDL cholesterol, HDL cholesterol, hs-CRP, homocysteine, intima-media thickness, arterial stiffness values were measured and statistically analyzed.
Results: It is determined that the levels of total choles­terol, triglyceride, LDL cholesterol, HDL cholesterol, ho­mocysteine, intima-media thickness, arterial stiffness and hs-CRP was higher in patients compared to the control group (in order; p=0.03, p=0.0006, p=0.02).
Conclusion: Carotid intima-media thickness being in­creased because of increased levels of homocysteine and inflammation in CAPD patients. Therefore, in case of atherosclerosis, hyperlipidemia and inflammation more aggressive treatment protocol should be considered. Pa­tients with elevated plasma homocysteine concentrations should be treated.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2016, Volume 7, Issue 1, 47-51

Publication date: 01 Mar 2016

Article Views: 1847

Article Downloads: 917

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