The effect of acute decompansated hearth failure treatment on oxidative stress
Turgay Ulaş 1 * , Hakan Büyükhatipoğlu, Yusuf Sezen, Mehmet Sinan Dal, Timuçin Aydoğan, Mehmet Ali Eren, Mehmet Uçar, Nurten Aksoy, Recep Demirbağ
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1 Harran Üniversitesi Tıp Fakültesi, İç Hastalıkları Ana Bilim Dalı, Şanlıurfa, Turkey
* Corresponding Author


Objectives: Myocardial dysfunction in patients with hearth failure is suggested to occur due to membrane changes caused by oxidative stress. The aim of this study is to evaluate whether there is a relationship between the degree of hearth failure and oxidative stress, and the effect of hearth failure therapy on oxidative stress parameters.
Materials and methods: We measured enzyme activities of catalase (CAT) and lipid hydroperoxide (LOOH) from blood samples of 67 patients with decompensate hearth failure (pre-treatment group), who have compensated with the treatment (post-treatment group, n=54) according to clinical findings and two-dimensional echocardiography and 47 healthy volunteers (control group).
Results: We found CAT enzyme activities of patients with pre- and post-treatment groups were significantly lower than in control subjects (15.76±2.28 U/L; 17.36±1.55 U/L; 20.50±2.52 U/L, respectively, p<0.0001). LOOH enzyme activities of pretreatment group was also significantly higher than in control group (10.89±3.83 μmol H2O2Eqv./L; 6.09±0.85 μmol H2O2 Eqv./L respectively, p<0.0001). In the same way, LOOH enzyme activities of posttreatment group was higher than pretreatment group and this was statistically significant (18.77±5.42 μmol H2O2Eqv./L; 10.96±3.72 μmol H2O2 Eqv./L respectively, p<0.0001).
Conclusion: As a result of our study, oxidative stress increased in patients with decompensated heart failure and compensation treatment also showed increased oxidative stress.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2011 - Volume 2 Issue 3, pp. 267-272

Publication date: 13 Sep 2011

Article Views: 1633

Article Downloads: 635

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