The comparison of antibody titers secondary to intramuscularly, subcutaneous or intradermal application of low dose Hepatitis B vaccine
Sabit Şahin 1 * , Yaşar Durmaz, Cengiz Yakıncı
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1 Elbistan Devlet Hastanesi Çocuk Sağlığı ve Hastalıkları Kliniği, K.Maraş, Turkey* Corresponding Author


Objectives: There are approximately 300 million HBV carriers where 25-30% of them had deceased due to cirrhosis or PHK. Universal vaccination is suggested worldwide against HBV because it is proven that vaccinating only the risk group is useless to reduce or eradicate the HB. However, the high costs limit its extensive usage. One way to reduce high costs is vaccinating in low dose. The purpose of this study is to determine the dependable, effective and low-cost dose as the result of evaluating the antibody titers against recombinant HB vaccine in three routes.
Materials and methods: Antibody titers against three times intramuscularly (IM), subcutaneous (SC) and intradermal (ID) in different doses like 4µg, 10µg or 20µg were detected.
Results: Totally, 96 newborn were chosen from HBsAg negative mothers and greater than 2500 gram in birth weight. They were randomly distributed into 7 groups. The recombinant HB vaccine (20 µg/0.5 ml. Gen-Hevac B. Pasteur Merieux) is applied as IM 20 µg (IM20) to 15, IM 10 µg (IM10) to 18, IM4µg (IM4) to 12, SC 20 µg to 12, SC 10 µg to 14, SC 4 µg to 10 and finally IM 4 µg to 15 babies after birth, at first month and sixth month. Six month after the third dose, the protective antibody titers gathered from the first four groups (100%, 93.4%, 91.6%, and 88.9% respectively) are accepted as sufficient.
Conclusion: The application of low dose (4 pg) Hepatitis-B Vaccine via intradermal resulted in desired immunization level without reducing immune response and by reducing the cost five times.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, Volume 2, Issue 3, September 2011, 277-281

Publication date: 13 Sep 2011

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Article Downloads: 2617

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