Serum S-100B levels in children with Subacute Sclerosing Panencephalitis
İbrahim Hocanlı, Mustafa Çalık 1 * , Alpay Çakmak, Hakim Çelik, Addürrahim Koçyiğit, Akın İşcan
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1 Harran University School of medicine, Department of Pediatric neurology Şanlıurfa, Turkey* Corresponding Author


Objectives: S-100B a protein prevalent in the central nervous system is a peripheral biomarker for blood-brain barrier disruption and neuronal damage. The objective of the study was to investigate the S-100B levels in patients with subacute sclerosing panencephalitis.
Materials and methods: A group of 40 patients with SSPE and 40 healthy controls were recruited. Serum S-100B protein concentrations were measured using a commercially available electrochemiluminescence immunoassay (ECLIA) kit, as supplied and according to the manufacturer's standards.
Results: Median S-100B levels were 0.095 ± 0.017 μg/L in patients with SSPE and 0.097±0.019 μg/L in the control group. This difference was not statistically significant (p>0.05). The patient group was further subdivided into two subgroups according to the presence or absence of brain atrophy. The S-100B levels were 0.096 ± 0.018 μg/L in the subgroup with atrophy and 0.094±0.014 μg/L in the subgroup without atrophy. This difference was also not statistically significant (p>0.05).
Conclusions: Our results suggest that serum S-100B is not a reliable marker for neuronal damage in SSPE.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2012, Volume 3, Issue 3, 331-334

Publication date: 11 Sep 2012

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Article Downloads: 741

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