Serum levels of prolidase and ischemia modified albumin in patients with multiple sclerosis
Mehmet Uğur Çevik 1 * , Yavuz Yücel, Adalet Arıkanoğlu, Sefer Varol, Eşref Akıl, Hatice Yüksel, Mehmet Ufuk Aluçlu
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1 Dicle üniversitesi Tıp Fakültesi Nöroloji AD, Diyarbakır, Turkey* Corresponding Author


Objectives: Increased levels of free radicals and oxidant molecules and decreased levels of antioxidant molecules have been defined in patients with multiple sclerosis (MS). Ischemia-modified albumin (IMA) levels have been advocated as a biomarker for evaluating the oxidative stress status. The aim of this study was to investigate the relationship between oxidative stress and MS.
Materials and methods: We compared serum ischemia modified albumin levels and prolidase activity of 42 patients with MS (30 female, 12 male) and 30 age-matched healthy controls (21 female, 9 male).
Results: Ischemia modified albumin levels of MS patients (73,07±26,53 ng/mL) were significantly higher than those of controls (60,18±18,01 ng/mL) (p=0.024). However, there were no significant differences in prolidase levels between patients and healthy controls (p=0.856).
Conclusions: Increased ischemia modified albumin levels, supports the role of oxidative stress in patients with multiple sclerosis.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, Volume 3, Issue 4, December 2012, 518-520

Publication date: 13 Dec 2012

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Article Downloads: 1203

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