Scrotal Calcinosis: Analysis of 5 Cases

J Clin Exp Invest 2018;9(4):150-153.


Download Full Text (PDF)


Idiopathic scrotal calcinosis (ISC) is an uncommon benign process, characterized by solitary or multiple, painless, strict scrotal nodules in the lack of systemic metabolic disorder. Its nature and reason have remained unknown and theories of origin contain idiopathic calcification arising within normal scrotal collagen, dystrophic calcification of inflamed scrotal epidermoid cysts, eccrine duct milia or dartoic muscle, and secondary to minor trauma. A total of 5 cases were found for ISC in our department of pathology. All patients underwent surgical excision of the lesions with overlying skin. Age range was from 25 to 49 years with a mean age of 31.4 years. Three of the patients with multiple lesions (3/5). The common appearance of the masses were hard, slowly growing, semi-mobile, lobulated, and well-circumscribed subcutaneous nodules. Diameter of the lesions ranged 0.7cm to 3cm. Grossly, there were firm, white with chalky and gritty areas. H&E stains revealed basophilic masses in dermis with foreign body giant cell reaction in 4 cases. No recurrences were noted. ISC is a rare, benign, disease of the scrotal skin that is characterized by calcium depositions of various sizes surrounded by a granulomatous reaction. In spite of the debate about the origin of this entity, surgery still seems to be the treatment of option and provides a good clinical outcome.


idiopathic, scrotum, calcinosis, dermis, histopathology


  • Lewinski HM. Lymphangioma der Haut mit verkalktem Inhalt. Virchows Arch Pathol Anat 1883;91:371-4.
  • Hutchinson J. Illustrations of clinical surgery. Vol 2, Balkiston, Philadelphia 1888.
  • Dubey S, Sharma R, Maheshwari V. Scrotal calcinosis: Idiopathic or dystrophic? Dermatology Online Journal 2010;16(2):5.
  • Shapiro L, Platt N, Torres-Rodríguez VM. Idiopathic calcinosis of the scrotum. Arch Dermatol. 1970;102(2):199-20
  • Swinehart JM, Golitz LE. Scrotal calcinosis. Dystrophic calcification of epidermoid cysts. Arch Dermatol. 1982;118(12):985-8.
  • Dare AJ, Axelsen RA. Scrotal calcinosis: origin from dystrophic calcification of eccrine duct milia. J Cutan Pathol. 1988;15(3):142-9.
  • King DT, Brosman S, Hirose FM, Gillespie LM. Idiopathic calcinosis of scrotum. Urology. 1979;14(1):92-4.
  • Feinstein A, Kahana M, Schewach-Millet M, Levy A. Idiopathic calcinosis and vitiligo of the scrotum. J Am Acad Dermatol. 1984;11(3):519-20.
  • Tela UM, Ibrahim MB. Scrotal Calcinosis: A Case Report and Review of Pathogenesis and Surgical Management. Hindawi Publishing Corporation Case Reports in Urology. 2012:1-3.
  • Andola SK, Karangadan S, Patil S. Idiopathic scrotal calcinosis: A case series. Indian Journal of Dermatopathology and Diagnostic Dermatology. 2014;1(2):86-9.
  • Michl UHG, Gross AJ, Loy V, Dieckmann KP. Idiopathic Calcinosis of the Scrotum-A specific entity of the scrotal skin. Scand J Urol Nephrol. 1994;28:213-7.
  • Coban YK, Aytekin AH, Aydin EN, Idiopathic calcinosis cutis of the vulva. Indian J Dermatol. 2013;58(6):464–6.
  • Wright S, Navsaria H, Leigh IM. Idiopathic scrotal calcinosis is idiopathic. J Am Acad Dermatol. 1991;24(5 Pt 1):727-30.


Kilitci A, Kaya Z, Acar EM, Elmas ÖF. Scrotal Calcinosis: Analysis of 5 Cases. J Clin Exp Invest. 2018;9(4):150-3.