Prognostic significance of c-erbB-2 and p53 expression in colorectal carcinoma
Aynur Albayrak 1 * , Nesrin Gürsan, Cemal Güngoğdu
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1 Dışkapı Yıldırım Beyazıt Education and Research Hospital, Dept. Pathology, Ankara, Turkey* Corresponding Author


Objective: Colorectal cancer is the fourth commonest form of cancer occurring worldwide. In order to recognize the prognosis in colorectal carcinoma, a lot of clinic and pathologic parameters such as; tumor size, microscopic type, microscopic grade, depth of invasion, lymph node involvement, invasion of vascular and perineural, tumor stage have been used. In this study, we aimed to compare expression of c-erbB-2, p53 and classical prognostic factors, and to investigate the correlation with prognosis.
Methods: In our study, operation materials belonging to 50 colorectal cases were examined retrospectively.
Results: Overall, 100 % of colorectal carcinomas had nuclear-staining for p53 protein and 78% of carcinomas cytoplasmic and membranous staining or the c-erbB-2 showing distribution in a heterogeneous fashion. p53 overexpression correlated with (p<0.005) pathologic stage, metastasis of lymph node, invasion of angiolymphatic, differentiation and degree of tumors. c-erbB-2 overexpressions correlated with (p<0,005) histologic differentiation and peritumoral lymphocytic infiltration but not correlated with tumor size, tumor growth pattern, localisation of tumors, pathologic stage, metastasis of lymph node, invasion of angiolymphatic.
Conclusion: These results suggest that evaluation of c-erbB-2 and p53 Immunohistochemical expression in colorectal carcinomas may be of value in predicting the clinical course in these patients.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, Volume 5, Issue 1, March 2014, 80-85

Publication date: 11 Mar 2014

Article Views: 2352

Article Downloads: 1569

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