Derya Uçmak 1 *
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1 Dicle Üniversitesi Tıp Fakültesi, Dermatoloji Kliniği, Diyarbakır, Turkey* Corresponding Author


Pemphigus is an uncommon autoimmune mucocutaneous blistering disease, mediated by antibodies directed against proteins present on the surface of keratinocytes that provide mechanical structure to the epidermis. Incidences of the various forms of pemphigus vary from country to country. Pemphigus vulgaris consists of the 80% of pemphigus cases and it occurs 10 times more than pemphigus foliaceus. There have been several recent advances in the management of pemphigus. Treatment of with systemic steroids and cytotoxic immunosuppressants can be highly effective. This article will discuss its epidemiology, pathogenesis, clinical variants and approaches to treatment.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Review

J Clin Exp Invest, 2011, Volume 2, Issue 4, 468-473

Publication date: 12 Dec 2011

Article Views: 2543

Article Downloads: 2164

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