Diagnostic value of urinary pyridinoline for determining bone metastasis in patients with non-metastatic breast cancer
Zeynep Giniş, Sevilay Sezer 1 * , Nuriye Özdemir, Fatma Uçar, Serpil Turhan
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1 Dıskapı Yıldırım Beyazıt Training and Research Hospital, Biochemistry Laboratory, Ankara, Turkey
* Corresponding Author


Objective: In this study, urinary pyridinoline (uPYR), urinary deoxypyridinoline (uDPD) and serum alkaline phosphatase (sALP) levels were measured in patients without metastatic breast cancer and the role of uPYR and uDPD as biochemical markers of bone metastases were examined during a six years follow-up.
Materials and methods: Totally, 34 patients without bone metastasis and 40 healthy individuals as a control group were included in the study.
Results: Urinary pyridinoline and uDPD levels were significantly higher in patients without bone metastasis than in normal controls (p<0,05), except sALP levels. As a result of a 6-year follow-up of patients, 20.5% had metastasis. The distribution of metastasis types was as follows: 2.9% of those patients had local, 2.9% had liver, 5.9% had lung and 8.8% had bone metastasis. The cut off value, sensitivity and specifity of uPYR was established as 47,3 pmol/µmol creatinin, 82% and 80% respectively. The cut off value, sensitivity and specifity of uDPD were determined as 9.53 pmol/µmol creatinin, 76%, 72% respectively.
Conclusions: This study demonstrated that measurement of urinary collagen cross-links assay may contribute to the early detection of metastatic spread to bone in breast cancer. However further studies with larger scaled groups should be performed.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article


J Clin Exp Invest, 2011 - Volume 2 Issue 4, pp. 420-424

Publication date: 12 Dec 2011

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