Diabetic rats: Hyperlipidemia and role of mango seed
Arfa Azhar 1 * , Farah Asad 2 , Fatma Rizvi 3 , Fatma Abid 2 , Mohammad Umair Farooqui 4
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1 Aga Khan University Hospital, Department of Biological and Biomedical Sciences, Karachi, Pakistan2 Jinnah Sindh Medical University, Department of Pharmacology, Karachi, Pakistan3 Dow University of Health Sciences, Department of Pharmacology, Karachi, Pakistan4 Shaheed Muhtarma Benazir Bhutto Medical University, Department of Pharmacy, Larkana, Pakistan* Corresponding Author


Background: Diabetes is a hyperglycemic disease caused by a lack of action of insulin, but serum lipids are also strongly affected by insulin. Serum lipid abnormalities (dyslipidemia) are frequently observed in diabetic populations regardless of insulin deficiency or insulin resistance. Hypertriglyceridemia is the greatest common serum lipid abnormality in diabetic populations. To study the effect of mango seeds on dyslipidemia in diabetes-induced rats. There was a noticeable difference in the body weight (BW) of male and female diabetic rats.
Materials and methods: To investigate effect on BW and the antihyperlipidemic actions of ethanolic extract of mango seed (EEMS) on alloxan-mediated diabetic Sprague-Dawley rats. Antihyperlipidemic in addition antidiabetic properties of an EEMS was planned at 100 and 200 mg/kg BW. The antidiabetic effect of EEMS been matched with tolbutamide 500 mg/kg BW. The lipid levels and BW of male and female rats were examined at consistent periods throughout the research.
Results: The outcomes displayed that the dyslipidemia was considerably decreased in the different treatment groups, while matched with control, the animals cured with tolbutamide and EEMS control.
Conclusion: EEMS exhibited a noteworthy antihyperlipidemic actions in addition with marked difference on BW of both male and female in alloxan-induced diabetic rats.


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Article Type: Research Article

J CLIN EXP INVEST, 2023, Volume 14, Issue 3, Article No: em00817


Publication date: 01 Jul 2023

Online publication date: 19 Apr 2023

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