Comparison of the effects of regional and general anesthesia on the immune system via cytokines in urooncologic surgery
Selda Yıldırım, Harun Aydoğan 1 * , Şaban Yalçın, Halil Çiftçi, Ahmet Küçük, Tekin Bilgiç, Fadile Yıldız Zeyrek
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1 Harran Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon AD, Şanlıurfa, Turkey* Corresponding Author


Objectives: In this study, it was aimed to compare effects of general anesthesia and spinal anesthesia on the im­mune system via serum cytokines interleukine 2 (IL-2), interleukine 4 (IL4), interleukine 6 (IL-6) in urologic cancer patients.
Methods: Forty-four, ASA physical status I–II patient, who were scheduled for urooncologic surgery with spinal or general anesthesia enrolled to the study. Demographic parameters, heart rate and mean blood pressure values were recorded. Venous blood samples were taken at pre­operative period and postoperatively 6th hours to deter­mine IL-2, IL-4 and IL-6 levels.
Results: There was no statistical significance between groups among heart rate and mean blood pressure val­ues. There were no significant difference in preopera­tive IL-2, IL-4, IL-6 and postoperative IL-2, IL-4 levels between groups, however postoperative IL-6 levels were significantly increased in general anesthesia group com­pared with spinal anesthesia group (p<0.05).
Conclusions: Preferred anesthetic method might influ­ence inflammatory response in addition to surgery in can­cer patients undergoing urooncologial surgery.


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Article Type: Research Article

J Clin Exp Invest, 2013, Volume 4, Issue 1, 51-55

Publication date: 14 Mar 2013

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Article Downloads: 1070

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