Objectives: The aim of this study was to examine clinical and laboratory characteristics of children with AGN in a tertiary university hospital.
Materials and methods: Hospital records of children, which hospitalized with AGN diagnosis in Pediatric Nephrology Unit, between 2004 and 2011, were retrospectively reviewed. Patients were divided into three subgroups as age <5 years, 5-10 years and >10 years. Characteristics at hospital admission including, blood pressure, diuresis state, serum urea, creatinine and electrolyte levels, complement factors C3 and C4, complete blood count and urine analysis results were recorded. Data about primary infection, treatments, disease course and outcome were recorded and analyzed.
Results: Totally 220 children (157 male, 71.2%; 63 female, 28.8%) were included. Probable etiological infections were tonsillopharyngitis in 133 (60.5%), pyoderma in 12 (5.5%), other infections in 27 (12.2%) children. In 48 (21.8) children with AGN, no primary infection were detected. Edema was found in 81.4% of patients, hypertension in 73.6%, and pulmonary stasis in 22.6%. Low C3 levels were found in 89.1%, azotemia in 45.9%, hematuria in 95.4%, nephritic proteinuria in 80.5%, and leukocyturia in 37.6% of patients. Diuresis was enabled within one week in 82%. Additional vasodilators were given to 45 (20.5%) patients, and hemodialysis was performed to three. Except for frequency of low C3 (p=0.018) and anemia (p=0.006), no significant differences were found in clinical and laboratory findings between age groups (p>0.05).
Conclusions: No difference was found in clinical and laboratory features of AGN based on age groups, excluding low C3 and anemia frequency.