Carotid intima-media thickness and neutrophils/lymphocytes ratio in patients with overt and subclinical hypothyroidism
Fahri Güneş 1 * , Mehmet Asik, Burak Altun, Hacer Sen, Emine Binnetoglu, Erdem Akbal, Sengul Ozcelik, Kubilay Ukinc
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1 Çanakkale Onsekiz Mart Üniversitesi İç Hastalıkları Anabilim Dalı, Çanakkale, Turkey* Corresponding Author


Objective: Hypothyroidism, whether overt or subclinical, has multiple effects on the cardiovascular system. Neutrophil-lymphocyte (N/L) rate is closely related to cardiovascular disorders and atherosclerosis. Our study aimed to assess N/L rate and carotid artery intima-media thickness (CIMT) in patients with overt and subclinical hypothyroidism (SCH).
Methods: The study included 36 patients with SCH and 28 patients with overt hypothyroidism (OH) as well as 30 healthy controls. CIMT, thyroid hormone levels, complete blood count and lipid parameters were measured in all subjects. Correlation analysis and linear regression analysis were performed for N/L rate.
Results: Mean CIMT was 0.51 ± 0.15, 0.58 ± 0.16, 0.67 ± 0.24 mm in control, SCH, and OH groups, respectively. CIMT of OH patients was high compared with control subjects (P < 0.05). CIMT of SCH patients were not different compared with control subjects and OH patients (P > 0.05). It was no correlation that CIMT between N/L ratio (p > 0.05).
Conclusion: Neutrophil-lymphocyte rate was not found to be useful indicator of early atherosclerosis in SCH and OH patients.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, Volume 4, Issue 4, December 2013, 463-467

Publication date: 14 Dec 2013

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Article Downloads: 1294

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