Biomarkers in the diagnosis of acute appendicitis
Mücahit Kapçı, Kenan Ahmet Türkdoğan 1 * , Ali Duman, Mücahit Avcil, Bedia Gülen, Ökkeş Taha Küçükdağlı, Yusuf Uğurlu, Yeliz Yılmaz
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1 Bezmialem Vakıf Üniversitesi, Tıp Fakültesi Acil Tıp Anabilim Dalı, İstanbul, Turkey* Corresponding Author


Objective: Patients who is presented to ED with the complaint of abdominal pain account an important number in the ED practice. Availability of rapid and inexpensive tests is crucial in the differential diagnosis of these patients. Hemogram parameters is one of them. In this study, we investigated the biomarkers in hemogram parameters of the patients diagnosed with acute appendicitis.
Methods: Data of 520 patients who were operated with the presumed diagnosis of appendicitis in our hospital between 01/01/2012 and 31/12/2013 were retrospectively screened. Of the 410 patients whom data were fully reached, leukocyte, neutrophil and lymphocyte counts, neutrophil / lymphocyte ratio (NLR), pathology results and at the admission time and superficial tissue ultrasonography (USG) reports if further investigation has been made were recorded.
Results: According to the pathological diagnosis of 334 patients (81.5%), while appendicitis 76 patients (18.5%) was not appendicitis. When taken 11,6 x103 for leukocyte, 8.5 x103 for neutrophil, 3.9 for NLO, while specificity of total  was 78.8%, sensitive 73.6% was found.
Conclusion: Together evaluation of neutrophils, lymphocytes and NLR which are routinely used hemogram parameters in association of physical examination is seem to be more appropriate.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, Volume 5, Issue 2, June 2014, 250-255

Publication date: 11 Jun 2014

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Article Downloads: 1688

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