Adenoidal tissue expression of CD23: An evaluation with reference to recurrent upper respiratory tract complaints and allergy in children
Demet Alaygut 1 * , Mehtat Unlu, Semih Sutay, Özkan Karaman, Özden Anal
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1 Dokuz Eylül University Hospital, Department of Pediatrics, İzmir, Turkey* Corresponding Author

Abstract

Objective: In this study, CD23, low affinity immunoglobu­lin E receptor, expression in the adenoid tissue was inves­tigated immunohistochemically and evaluated with regard to upper respiratory tract infection complaints and allergy.
Methods: This retrospective study was performed by the selection of 100 patients aged 2-13 years who underwent adenoidectomy/adenotonsillectomy and in whom the ad­enoid tissue pathological studies were reported as “lym­phoid hyperplasia and chronic infection” were evaluated. Immunohistochemical evaluation of CD23 expression was scored semiquantitatively between 0-3 in the tissue samples.
Results: The mean age in the study group was 70.7 months; 46% were female; 30% of patients had adenoid­ectomy only. Following the operation, the infection fre­quency decreased in 91% of patients, whereas allergy symptoms were unchanged in 84%. CD23 expression was found significantly lower in patients who had allergic manifestations, namely urticaria (p=0.041), drug sensitiv­ity (p=0.035) and pollen allergy (p=0.037).
Conclusion: A significantly reduced CD23 expression was found in adenoidal tissue in patients with allergic symptoms. These results can be assessed as an under­lying mechanism for the recurrence of respiratory tract complaints in these children, despite adenoidectomy.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2013, Volume 4, Issue 1, 1-7

https://doi.org/10.5799/ahinjs.01.2013.01.0225

Publication date: 14 Mar 2013

Article Views: 2412

Article Downloads: 1082

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