Adenoidal tissue expression of CD23: An evaluation with reference to recurrent upper respiratory tract complaints and allergy in children
Demet Alaygut 1 * , Mehtat Unlu, Semih Sutay, Özkan Karaman, Özden Anal
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1 Dokuz Eylül University Hospital, Department of Pediatrics, İzmir, Turkey* Corresponding Author


Objective: In this study, CD23, low affinity immunoglobu­lin E receptor, expression in the adenoid tissue was inves­tigated immunohistochemically and evaluated with regard to upper respiratory tract infection complaints and allergy.
Methods: This retrospective study was performed by the selection of 100 patients aged 2-13 years who underwent adenoidectomy/adenotonsillectomy and in whom the ad­enoid tissue pathological studies were reported as “lym­phoid hyperplasia and chronic infection” were evaluated. Immunohistochemical evaluation of CD23 expression was scored semiquantitatively between 0-3 in the tissue samples.
Results: The mean age in the study group was 70.7 months; 46% were female; 30% of patients had adenoid­ectomy only. Following the operation, the infection fre­quency decreased in 91% of patients, whereas allergy symptoms were unchanged in 84%. CD23 expression was found significantly lower in patients who had allergic manifestations, namely urticaria (p=0.041), drug sensitiv­ity (p=0.035) and pollen allergy (p=0.037).
Conclusion: A significantly reduced CD23 expression was found in adenoidal tissue in patients with allergic symptoms. These results can be assessed as an under­lying mechanism for the recurrence of respiratory tract complaints in these children, despite adenoidectomy.


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Article Type: Research Article

J Clin Exp Invest, 2013, Volume 4, Issue 1, 1-7

Publication date: 14 Mar 2013

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Article Downloads: 1082

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