Relationship Between Tetanus Antitoxin Titration Level and Vaccination History
Meltem Işıkgöz Taşbakan, Raika Durusoy, Selma Tosun, Deniz Akyol, Hüsnü Pullukçu, Tansu Yamazhan
J Clin Exp Invest 2017;8(4):104-109.
https://doi.org/10.5799/jcei.382398
Research Article
[Abstract]
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ABSTRACT
Objectives: We aimed to determine tetanus antitoxin levels and to evaluate their relationship with history of vaccination among patients applying to the outpatient clinics of a University hospital.
Methods: A questionnaire including socio-demographic characteristics and tetanus vaccination status was applied and blood samples taken from 218 subjects between 1 and 30 June 2015. Participants were classified into five groups according to their vaccination timing.
Results: The mean age of participants was 46.7±15.4 years and 134 (61.5%) were women. Tetanus antitoxin levels were found weak positive in 54 (24.8%) patients, positive in 44 (20.2%) and strong positive in 120 (55.0%). Tetanus antitoxin level positivity was significantly associated with vaccination timing according to history. Among 105 participants who did not remember being vaccinated or who knew they were vaccinated but did not remember the date, 16 (15.2%) remembered the vaccination time when their injury, military service and pregnancy were questioned specifically. Antitoxin levels decreased with increasing age independent of gender (0.9-fold increase/year).
Conclusion: We found that the booster dose recommended every 10 years was not applied sufficiently. Tetanus vaccination history must be questioned in more detail among people who do not remember/know their vaccination history, with specific questions regarding pregnancy, military service and injury histories.
Keywords: C.tetani, tetanus, vaccine, immunization history
Evaluation of Usefulness of Cardiopulmonary Resuscitation Education on Public Health Physicians
Ahmet Baydin, Latif Duran, Erdinç Şengüldür, Celal Katı, Leman Tomak
J Clin Exp Invest 2017;8(4):110-113.
https://doi.org/10.5799/jcei.382406
Research Article
[Abstract]
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ABSTRACT
Objective: Cardiopulmonary resuscitation (CPR) is a life-saving process in which many disciplines are involved. In this study, our aim was to evaluate CPR knowledge of public health physicians and determine usefulness of education on this important topic.
Methods: A total of 337 public health physicians were involved in an educational course and asked to answer a questionnaire both before and after the course. The questionnaire involved 26 questions and participants’ personal identifiers were hidden. The results of two questionnaires were compared.
Results: We achieved improvement in knowledge of 315 participants. In majority of the participants, the number of the right answers increased up to 6 to 10 points. We also determined that those who attended to a similar educational course before were more successful than those who did not.
Conclusion: Education on CPR is essential for every discipline involved in medicine. Increasing the knowledge of physicians may decrease mortality and morbidity related to sudden cardiac arrest. Institutions must be encouraged for continuous educational organizations and participation of health care providers from different disciplines must be assured.
Keywords: Cardiopulmonary resuscitation, education, public health physician
The evaluation of the low risk pregnant women who gave birth to macrosomic infants
Ali Özgür Ersoy, Efser Öztaş, Sibel Özler, Ebru Ersoy, Hasan Onur Topçu, Rahime Bedir Fındık, Yasemin Taşçı
J Clin Exp Invest 2017;8(4):114-119.
https://doi.org/10.5799/jcei.382414
Research Article
[Abstract]
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ABSTRACT
Objective: Fetal macrosomia is an important entity that effects maternal, fetal and neonatal well-being. Our aim was to investigate the maternal factors which cause fetal macrosomia and to investigate the pregnancy outcomes.
Patients and Methods: Three hundred forty-eight low-risk women who attended to our tertiary care institution for delivery and gave birth to a macrosomic infant were recruited as the study group, and 474 low-risk women who gave birth to a non-macrosomic infant were recruited as the control group. Individual, laboratorial characteristics, and neonatal health variables were compared between two groups.
Results: Maternal age, prepregnancy and peripartum body mass indices, weight gain during pregnancy and parity values in the study group were more than the control group. Birth weights of the babies correlated significantly with gestational age at birth and parity values. Fasting blood glucose levels of the mothers in the macrosomia group were significantly higher than the control group.
Conclusions: Women who gave birth to a macrosomic infant were older, more obese, gained more weight in the pregnancy period, had more parity, delivered at a later gestational age than women who gave birth to a non-macrosomic infant. Birth weight of the baby increases with increasing fasting blood glucose levels, even if the pregnant woman does not have any type of diabetes in pregnancy. The risks of neonatal hypoglycemia and hyperbilirubinemia, and the need for neonatal intensive care unit were more frequent in macrosomic infants.
Keywords: Birth weight, macrosomia, parity, pregnancy outcome
Acute Otitis Media Complications
Cüneyt Kucur, İsa Özbay, Muhammet Fatih Topuz, Onur Erdoğan, Fatih Oğhan, Ali Güvey, Nadir Yıldırım
J Clin Exp Invest 2017;8(4):120-123.
https://doi.org/10.5799/jcei.382431
Research Article
[Abstract]
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ABSTRACT
Objective: Acute otitis media is the result of viral or bacterial infections in the middle ear. Despite the frequent use of antibiotics for different reasons, it can still be present with serious complications. Although acute otitis media is most common between ages 3 months - 3 years, it can be seen in adults and even it may result in serious complications too.
Patients and Methods: Our study was carried out by retrospectively screening patients who were admitted to Dumlupınar University Evliya Çelebi Training and Research Hospital between January 2013 and June 2015 for acute otitis media. During these years, hospital data of patients who have referred to our hospital have been reviewed for intracranial and intratemporal complications.
Results: A total of 2475 patients with acute otitis media were included. Intracranial and intratemporal complications were observed in 16 patients. The most frequent complications were mastoiditis (in 4 patients), subperiosteal abscess, facial nerve palsy and meningitis (each in three patients). Acute labyrhintitis developed in two patients and petrositis in one.
Conclusion: Despite the current preventive and therapeutic approaches, patients with acute otitis media can still present with complications.
Keywords: Acute otitis media, complications, otitis media complications
Labile hemoglobin A1c: a factor affecting the estimation of glycated hemoglobin
Kalpana Singh, Bhawna Mahajan, Shweta Singh, Abbas Ali Mahdi
J Clin Exp Invest 2017;8(4):124-126.
https://doi.org/10.5799/jcei.382433
Brief Report
[Abstract]
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ABSTRACT
Labile hemoglobin A1c (also known as pre-HbA1c or LA1c or pre-glycohemoglobin) an unstable form, is a Schiff base formed during non-enzymatic glycation of hemoglobin. The concentration of labile fraction varies with acute change in plasma glucose level. Labile hemoglobin A1c fraction cannot be separated from the stable ketoamine fraction by most of the methods available for estimation of glycated hemoglobin (HbA1c). Though ion-exchange HPLC (high pressure liquid chromatography) method can separate the labile HbA1c fraction, but in some situation abnormally high level of this fraction may serve as a pre-analytical error interfering in estimation of glycated hemoglobin. By focusing on the hemoglobin chromatogram, reporting of this pre-analytical error can be minimized in HPLC method.
Keywords: Diabetes, Glycated hemoglobin, HPLC, Labile hemoglobin
Geotrichum candidum: A rare infection agent at urinary system and review of the literature
Fulya Bayındır Bilman, Mevliye Yetik
J Clin Exp Invest 2017;8(4):127-129.
https://doi.org/10.5799/jcei.382434
Case Report
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ABSTRACT
Geotrichum is a species of fungi that can be found in every environment in nature, in soil, in water and in air. As it can be found in plants and in cereals and milk products, it has also been shown to be found in normal human flora (mucus and faeces). Geotrichum candidum, mostly saprophytic, can cause clinical picture called Geotrichosis. Neoplasms, leukosis, HIV infection, diabetes mellitus, and kidney transplantation are generally the underlying diseases in such cases. In a case in which we detected G.candidum reproduction in urinary tract infection, we aimed to present the case with its clinic findings and to review the literature.
Keywords: Geotrichum candidum, Geotrichosis, fungus, immunsupressive host