Ultrasound evaluation of metabolic syndrome patients with hepatosteatosis
Mehmet Emin Demir 1 *
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1 Harran Üniversitesi Tıp Fakültesi, Nefroloji BD, Şanlıurfa, Turkey* Corresponding Author


Objective: The exact incidence of hepatosteatosis in pa­tients with metabolic syndrome (MetS) is unknown; also there is no valid, simple and inexpensive method to evaluate and follow-up for patients with MetS. In our study, we aimed to demonstrate the frequency of hepatosteatosis, and wheth­er demonstrate presence and degree of steatosis using liver ultrasonography may provide additional benefit for evaluat­ing and following-up in MetS patients with non-alcoholic fatty liver disease.
Methods: One hundred and twelve patients with MetS were included to the study. Patients divided into three groups; con­trol group (n= 36) consisted of patients without hepatosteato­sis, group 1 (n=43) consisted of patients with grade 1 hep­atosteatosis. Finally, group 2 (n= 33) consisted of patients with grade 2 hepatosteatosis. The relationship between the presence and degree of the hepatosteatosis and MetS pa­rameters were analyzed.
Results: The incidence of hepatosteatosis was found 69.4% in patients with MetS. There were significantly differences in HOMA-IR, AST, ALT and GGT levels among control group and group 1 (p<0.05 for all). There were also significantly dif­ferences in waist circumference, fasting blood glucose, fast­ing insulin, HOMA-IR, AST, ALT, GGT, ferritin, CRP, sedimen­tation, uric acid and microalbuminuria levels among control group and group 2 (p<0.05 for all). Blood pressures and lipid profiles were similar among all groups (p>0.05 for all). Be­sides, there were significantly differences in waist circumfer­ences, fasting insulin, HOMA-IR, GGT, uric acid, CRP levels among group 1 and 2 (p<0.05 for all).
Conclusion: Our study indicates that MetS related parame­ters; especially insulin resistance, were significantly different in patients with hepatosteatosis compared to patients with­out hepatosteatosis. Because of the different measurment of waist circumferences among groups, we recommend to use liver ultrasonography and waist circumference together to evaluate and follow-up for MetS patients with hepatoste­atosis.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2013, Volume 4, Issue 2, 153-158


Publication date: 13 Jun 2013

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Article Downloads: 1332

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