Transformation of chronic lymphocytic leukemia to mantle cell lymphoma: A case report
Özlem Şahin Balcık, Derya Akdeniz 1 * , Kadir Serkan Yalçın, Ümit Akyıldız, Esra Atıcı, Sonay Güven, Ali Koşar
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1 Fatih Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, Ankara, Turkey* Corresponding Author


Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clonal expansion of B lymphocytes. Richter Transformation (RT) must be considered if CLL patient had fever, weight loss, cytopenia and resistance to standard therapy. Despite CLL usually transforms to diffuse large cell lymphoma, some rare lymphomas may occur as RT such as Hodgkin variants, lymphoblastic lymphoma nad mantle cell lymphoma. Here, we report a case of Mantle cell lymphoma has become secondary to chronic lymphocytic leukemia due to its being a rare entity.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Case Report

J Clin Exp Invest, 2011, Volume 2, Issue 4, 443-445

Publication date: 12 Dec 2011

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Article Downloads: 2784

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