Thyroid Diseases and Treatment in Pregnancy
Aynur Aktaş 1 * , Zafer Pekkolay
More Detail
1 Ankara Eğitim ve Araştırma Hastanesi Endokrin ve Metabolizma Hastalıkları, Şükriye Mahallesi, Ulucanlar Caddesi, No:89 Altındağ / Ankara, Turkey* Corresponding Author


Assessment of thyroid disease in pregnancy is important for gestational maternal health, obstetric outcome and, subsequent development of child. Pregnancy has pro­found effects on the regulation of thyroid function, and on thyroidal functional disorders, that need to be recognized, carefully evaluated and correctly managed. In women with normal thyroid function there is an increase in thyroxine (T4) and triiodothyronine (T3) production and inhibition of thyroid-stimulating hormone (TSH) in the first trimester of pregnancy,. In the pregnant woman, elevated thyroxine-binding globulin (TGB) and concomitant increases in total T4 and T3 levels plateau at 12-14 weeks of pregnancy, and free T4 measurements slowly decrease. The most frequent thyroid disorder in pregnancy is maternal hy­pothyroidism. It is associated with fetal loss, placental abruptions, preeclampsia, preterm delivery and reduced intellectual function in the offspring. Hyperthyroidism dur­ing pregnancy is relatively uncommon, with a prevalence estimated to range between 0.1% and 1%. The most common cause of hyperthyroidism is Graves disease, as this etiology accounts for 85% of clinical hyperthyroid­ism in pregnancy. Another cause of hyperthyroidism is hyperemesis gravidarum. This is common and requires differentiation from Graves disease. There has been much discussion and many publications on the optimal management of pregnant women who are hyperthyroid or hypothyroid. Despite the lack of consensus organiza­tions, which are based on analyses, support screening in all pregnant women in the first trimester for thyroid disease. In this article, we provide information about the current approaches of thyroid dysfunction in pregnancy.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Review

J Clin Exp Invest, 2016, Volume 7, Issue 1, 120-124

Publication date: 01 Mar 2016

Article Views: 1967

Article Downloads: 2848

Open Access References How to cite this article