This study supports the idea that stress contributes to the autoimmune diseases. It provides examples from different studies and shows some autoimmune diseases caused by the brain and the body. It is thought that stress affects the musculoskeletal, respiratory, cardiovascular, gastrointestinal, endocrine, nervous, and reproductive systems in a negative way. The human body can handle stress in small doses. If the stress lasts for a long-term period or becomes chronic, significant negative effects are expected to occur in the body. The chemical reaction in the body can also change with the impact of stress. It is not confidently concluded that stress causes the autoimmune diseases but the idea can be strongly encouraged according to the conditions found in and interpreted from the literature.