The Relationship of Vitamin B12 Deficiency and Red Cell Distribution Width-Platelet Ratio
Nigar Yılmaz, Mustafa Yılmaz
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Abstract

Objective: We aimed to investigate the relationship between vitamin B12 deficiency and red cell distribution width- platelet ratio (RPR), and the variations in the parameters on vitamin B12 treatment. Methods: One hundred fifty-four patients with untreated vitamin B12 deficiency (56% men, mean age: 50 ± 12.7 years) (untreated group), 86 patients with vitamin B12 deficiency (62% men, mean age: 42 ± 20.7 years) on vitamin B12 treat- ment (treated group), and 92 age- and sex-matched control group (54% men, mean age: 45 ± 15.1 years) were included in the study. Hematological parameters were evaluated by the method of laser-based flow cytometric impedance, using an automated blood cell counter (ABX Pentra 120 Hematology Blood Analyzer). Results: RPR was significantly reduced in treated group compared with untreated group (4.88 ± 1.06; 6.13 ± 1.27; p<0.001, respectively). RPR, red cell distribution width (RDW) and mean platelet volume (MPV) were significantly differ- ent in untreated group compared to controls (p<0.05). There were no differences in platelet count in the three groups (p>0.05). Conclusion: We proposed that vitamin B12 deficiency has effects on RPR and supplementation with vitamin B12 cor- rects the RPR levels.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

https://doi.org/10.5799/jcei.328604

J Clin Exp Invest, 2016 - Volume 7 Issue 3, pp. 211-215

Publication date: 01 Sep 2016

Article Views: 1039

Article Downloads: 435

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