The protective role of selenium in an experimental high fructose corn syrup exposure
Ozlem Sanli Esme 1 , Hasan Basri Savas 2 * , Mehmet Enes Sozen 3 , Elina Dinc 1
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1 Alanya Alaaddin Keykubat University, Graduate Education Institute, Department of Molecular Medicine, Antalya, Turkey2 Mardin Artuklu University, Faculty of Medicine, Department of Medical Biochemistry, Mardin, Turkey3 Alanya Alaaddin Keykubat University, Medical Faculty, Department of Histology and Embryology, Antalya, Turkey * Corresponding Author


Objective: Nowadays, fructose is recognized as a significant health threat. Prepared foods containing fructose are consumed more because they do not create a feeling of satiety. Selenium is an essential trace element with antioxidant and cell protective properties. In this study, the effect of high fructose corn syrup, which is used as a sweetener in many foods and beverages and consumed during pregnancy, and the possible protective role of selenium in this effect were investigated and examined.
Methods: Fertilized specific pathogen-free eggs were used in our study. These eggs were divided equally into four groups. Each group was allocated 10 eggs containing viable embryos. These groups are pre-process control, post-process control, high fructose corn syrup (HFCS-55), and high fructose corn syrup and selenium (HFCS-55+Se 10-6) groups. Pellets containing and containing no active substance (HFCS-55, HFCS-55+Se 10-6) were carefully placed on the chorioallantoic membrane (CAM) of each egg in these groups. Oxidative stress status in all groups was determined by total oxidative stress (TOS) and total antioxidant capacity (TAC) methods.
Results: In our study, a significant increase in TOS levels and a significant decrease in TAC levels were observed in egg groups given HFCS compared to other groups (p<0.05). The OSI value was shown to be lower in the group given HFCS+Se.
Conclusion: As a result, HFCS was shown to increase oxidative stress. In line with our data, it has been shown that Se, plays a protective role against oxidative stress.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J CLIN EXP INVEST, 2023, Volume 14, Issue 2, Article No: em00814

Publication date: 01 Apr 2023

Online publication date: 25 Feb 2023

Article Views: 732

Article Downloads: 416

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