Atopic dermatitis (AD) is a very common and recurrent chronic an inflammatory skin diseases. Atopic dermatitis is a health problem for especially industrialized countries. However in recent years AD has been more common in our country. Multiple factors play role in the pathogenesis of AD. Although the etiology is not clear, it may be related to immunologically deviated T cell functions with precipitating factors in genetically predisposed people. In present article, we reviewed actual literature on the etiopathogenesis of AD.