The impact of serum 25-hydroxyvitamin D level on migraine headache
Gökhan Özer
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Objective: To investigate the impact of serum 25-hydroxyvitamin D levels on migraine headache in migraineurs
Patients and Methods: A total of 72 patients were included in the study. Serum vitamin D concentration and its impact on the migraine headache were assessed in migraineurs and migraine subgroups. To assess serum levels of vitamin D, 25(OH) D3 was measured by enzyme-linked immunosorbent assay (ELISA). Patients were categorized as follows based on the results of serum vitamin D measurements. Severity of migraine, average duration and frequency of attacks per month were recorded. The headache diary result (HDR) was determined as: Duration of headache × frequency of headache.
Results: Average vitamin D level was 7.4 ng/ml among patients with migraine with aura group and 8.5 ng/ml in patients with migraine without aura. Severe vitamin D deficiency was detected in 14 (66.7%) patients with migraine with aura and 9 (64.3%) patients with migraine without aura, with no statistically significant difference between the two groups. No significant correlation was found between vitamin D levels and HDR among migraineurs (r=-0.042, p=0.812) as well as in patients with migraine with aura (r=0.044, p=0.842) and in patients with migraine without aura (r=0.059, p=0.842) versus control group with respect to HDR and vitamin D levels. The severity of migraine pain was not associated with vitamin D levels. Serum vitamin D concentration was lower in male patients versus control group.
Conclusion: The impact of vitamin D on the severity and number of migraine attacks is not clear. Further studies are needed to demonstrate the association between vitamin D status and neurological diseases.


This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2018 - Volume 9 Issue 1, pp. 40-44

Publication date: 10 Mar 2018

Article Views: 1231

Article Downloads: 620

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