The effect of smoking on the response to raloxifene treatment in postmenopausal osteoporosis
Savaş Erdem, Ayşe Filiz Avşar, Hüseyin Levent Keskin, Gülin Feykan Yeğin 1 * , Elçin İşlek
More Detail
1 Dept. Gynecology and Obstetrics, Atatürk Education and Research Hospital, Ankara, Turkey
* Corresponding Author

Abstract

Objectives: The aim of this study was to examine the effect of smoking on the efficacy of raloxifene treatment in postmenopausal osteoporosis.
Materials and methods: In this cross-sectional study, raloxifene HCl (60 mg/day) and 600 mg ionized calcium + 400 IU vitamin D/day treatment were given to 63 cases (nonsmoker group n = 39, smoker group n = 24), who were in the postmenopausal period and detected as having osteoporosis. At the end of the first year of the treatment, the bone mineral densities (BMDs; g/cm2) were measured at four regions, namely the femur neck, femur trochanter, total hip, and lumbar vertebrae between L1-4, and T-scores were determined. The changes in BMDs were compared between the two groups.
Results: Before starting the treatment, the mean ages (55.8 ± 3.3 vs. 53.0 ± 1.3 years), menopausal ages (49.3 ± 2.9 vs. 48.1 ± 2.1 years), postmenopausal periods (5.0 ± 1.3 vs. 7.0 ± 1.4 years), body mass indexes, and estradiol levels were found to be significantly not different between the two groups (p > 0.05). At the beginning of treatment, the BMD values were not different for all measured regions in both groups (p > 0.05). At the end of the first year of the treatment, statistically significant improvements in BMD values and T-scores were detected for all measured regions in the nonsmoker group (p < 0.05). However, there were no significant differences in the BMD values from the initial values in the smoker group after treatment (p > 0.05).
Conclusions: The treatment efficacy of raloxifene in improving BMD values in postmenopausal osteoporosis is negatively influenced by smoking. J

License

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

https://doi.org/10.5799/ahinjs.01.2012.04.0202

J Clin Exp Invest, 2012 - Volume 3 Issue 4, pp. 457-462

Publication date: 13 Dec 2012

Article Views: 1482

Article Downloads: 438

Open Access References How to cite this article