The change of antibiotic resistance profiles over the years in Pseudomonas aeruginosa and Acinetobacter baumannii strains isolated from intensive care units
M. Cem Şirin 1 * , Neval Ağuş, Nisel Yılmaz, Yeşer Karaca Derici, Sevgi Yılmaz Hancı, Arzu Bayram, Pınar Şamlıoğlu
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1 Tepecik Eğitim ve Araştırma Hastanesi Tıbbi Mikrobiyoloji Laboratuvarı, İzmir, Turkey* Corresponding Author

Abstract

Objective: The aim of this study was to determine the antibiotic resistance profiles of Pseudomonas aeruginosa and Acinetobacter baumanniistrains isolated from patients in our hospital intensive care units (ICUs) between the years 2011-2014 and to investigate the changes of these profiles over the years.
Methods: Identification and antibiotic susceptibility testing of the strains were performed by automated system. Cefoperazone-sulbactam and tigecycline susceptibility was determined by disk diffusion method. Imipenem, meropenem and colistin resistance was confirmed by E-test method. Chi-square and Fisher's exact test were used to compare the antibiotic susceptibilities statistically.
Results: The highest resistance rates were determined for imipenem (50.2%), meropenem (51.9%) and piperacillin-tazobactam (64.0%) in P. aeruginosa strains (n=722). The changes in the rates of antibiotic resistance were not statistically significant in P. aeruginosa strains between the years 2011 and 2014. The decrease in gentamicin, amikacin and trimethoprim-sulfamethoxazole resistance and the increase in cefoperazone-sulbactam and tigecycline resistance was found to be statistically significant in A. baumannii strains (n=1044) between the years 2011 and 2014. The increase in imipenem and meropenem resistance was found to be statistically significant between the years 2012 and 2013. Piperacillin-tazobactam, ceftazidime, cefepime, imipenem and meropenem resistances in A. baumannii strains were found to be over 95% in all the years. Colistin was found to be the most effective antimicrobial agent for both bacteria.
Conclusion: The determination of considerably high antibiotic resistance rates in P. aeruginosa and A. baumannii strains isolated from our hospital ICUs has indicated that rational antibiotic use policies and more effective infection control programs should be applied along with monitoring the antibiotic susceptibility profiles constantly.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2015, Volume 6, Issue 3, 279-285

https://doi.org/10.5799/ahinjs.01.2015.03.0533

Publication date: 25 Oct 2015

Article Views: 2153

Article Downloads: 1313

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