Tear levels of macrophage migration inhibitory factor in vernal keratoconjunctivitis

J Clin Exp Invest 2013;4(2):195-198.



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Objective: The pathogenesis of vernal keratoconjunctivi­tis (VKC) is not fully understood and cannot be explained only with type I hypersensitivity reaction. The aim of this study was to determine the Macrophage migration inhibi­tory factor (MIF) levels in tear fluids of patients with VKC.
Methods: Tear fluid samples were collected with micro­capillary tubes for hematocrit at the lateral canthus of patients in the supine position without any anesthesia. Tear levels of MIF were measured by ELISA kit. Tear fluid samples were collected from 10 healthy subjects and 20 patients with VKC.
Results: Tear levels of MIF in patients with VKC were significantly higher than those in controls (p<0,001).
Conclusion: These results suggested that MIF may have significant effect on the pathogenetic process of VKC.


Macrophage migration inhibitory factor, ver­nal keratoconjunctivitis, ELISA


Çatak O, Aydemir O, Üstündağ B. Tear levels of macrophage migration inhibitory factor in vernal keratoconjunctivitis. J Clin Exp Invest. 2013;4(2):195-8. https://doi.org/10.5799/ahinjs.01.2013.02.0264