Tear levels of macrophage migration inhibitory factor in vernal keratoconjunctivitis
Onur Çatak 1 * , Orhan Aydemir, Bilal Üstündağ
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1 Elazığ Eğitim ve Araştırma Hastanesi Göz Bölümü Elazığ Turkey* Corresponding Author


Objective: The pathogenesis of vernal keratoconjunctivi­tis (VKC) is not fully understood and cannot be explained only with type I hypersensitivity reaction. The aim of this study was to determine the Macrophage migration inhibi­tory factor (MIF) levels in tear fluids of patients with VKC.
Methods: Tear fluid samples were collected with micro­capillary tubes for hematocrit at the lateral canthus of patients in the supine position without any anesthesia. Tear levels of MIF were measured by ELISA kit. Tear fluid samples were collected from 10 healthy subjects and 20 patients with VKC.
Results: Tear levels of MIF in patients with VKC were significantly higher than those in controls (p<0,001).
Conclusion: These results suggested that MIF may have significant effect on the pathogenetic process of VKC.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2013, Volume 4, Issue 2, 195-198


Publication date: 13 Jun 2013

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Article Downloads: 900

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