Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer
Mahsuk Taylan 1 * , Sibel Arınç, Aysun Kosif Mısırlıoğlu, Mehmet Sinan Bodur, Selahattin Öztaş, Mevlut Karataş, ilim Irmak, Huseyin Arpag, Armağan Hazar
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1 Dicle University Faculty of Medicine, Department of Chest Disease, 21020 Diyarbakir, Turkey
* Corresponding Author

Abstract

Objective: The early and local advanced stages (IA-IIIA) of non-small cell lung cancer (NSCLC) warrant the curative treatment approach of surgery. However, despite the surgical approach, survival depends on a number of factors. The aim of the study was to examine the factors that affect survival in operated NSCLC patients with these stages.
Methods: A cohort of 231 operated patients with IA, IB, IIA, IIB, and IIIA stages of NSCLC were analyzed. The effects of age, sex, comorbidity, performance status, histopathology of the tumor, T stage, N stage, pleural invasion, surgical resection type and postoperative resection margin invasion on the survival of the patients were examined with Kaplan-Meier and Cox Regression analyses.
Results: Advanced age (OR=1.042 for every passing year, CI=1.020-1.064), adenocarcinoma histopathology (OR=1.676 CI=1.178-2.384), N2 invasion (OR=2.389 CI=1.46-4.239), pleural invasion (OR=2.403 CI=1.569-3.678), resection margin invasion (OR=2.401, CI=1.141-5.048) and pneumonectomy as the type of surgical operation (OR=2.313, CI=1.467-3.647) were found to be independent prognostic factors of mortality.
Conclusion: Follow-up of the NSCLC cases with advanced age, an adenocarcinoma type, visceral pleural invasion, N2-lymph node invasion, a history of pneumonectomy, and a resection margin invasion should be undertaken more atten­tively during planning of surgical operation and postoperative period.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

https://doi.org/10.5799/ahinjs.01.2016.02.0584

J Clin Exp Invest, 2016 - Volume 7 Issue 2, pp. 125-133

Publication date: 10 Jun 2016

Article Views: 3414

Article Downloads: 688

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