Serum paraoxanase-1 activity in patients with acute otitis media
Sema Koç 1 * , Fazilet Duygu, Ahmet Eyibilen, Nurten Aksoy, Abdullah Taskin, Hasan Bilinc
More Detail
1 Department of Otorhinolaryngology, School of Medicine, Gaziosmanpaşa University, Tokat, Turkey* Corresponding Author

Abstract

Objectives: Paraoxonase is a high-density lipoprotein (HDL)-associated antioxidant enzyme. We aimed to compare the activity of serum paraoxanase-1 (PON 1) in healthy controls and patients with acute otitis media (AOM).
Subjects and methods: We performed a prospective controlled trial in patients with AOM. A total of 60 subjects, 30 patients with AOM (17 male; age, 15 ± 9 years) and 30 age- and sex-matched controls (16 male; age, 16 ± 5 years) were enrolled in this study. PON 1 activity was measured using Mackness’ methods.
Results: PON 1 activity was significantly lower in the AOM group compared to control group (155 ± 95 U/L vs. 210 ± 96 U/L, P=0.04).
Conclusions: The present study demostrates that serum PON 1 activity is low in AOM, similar to other conditions with increased oxidative stress. We speculate that PON 1 enzyme is consumed at a greater rate during AOM in order to prevent increased oxidative damage.

License

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, Volume 2, Issue 4, December 2011, 412-415

https://doi.org/10.5799/ahinjs.01.2011.04.0083

Publication date: 12 Dec 2011

Article Views: 2532

Article Downloads: 952

Open Access References How to cite this article