Relationships between oxidative stress and sleep parameters in patients with obstructive sleep apnea syndrome
Özlem Abakay, Hadice Selimoğlu Şen, Hatice Yüksel, Süreyya Yılmaz, Yılmaz Palanci, Abdullah Çetin Tanrıkulu, Abdurrahman Abakay 1 *
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1 Dicle Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı, Diyarbakır, Turkey* Corresponding Author


Objective: Oxidative stress is characterized byan imbalance between production and destruction of reactive oxygen species. In our study, we aimed to determine the relationship between the oxidant-antioxidant balance in patients with showing some biochemical factors reflecting the severity of the disease and sleep parameters in patients with Obstructive Sleep Apnea Syndrome (OSAS).
Methods: 93 patients were included to the study at the sleep centre, Department of Chest Diseases, Dicle University Hospital. All patients were subjected to all night polysomnography. Serum TOS and TAS levels were measured.
Results: The mean age of patients was 47.4±7.2 years. There was not significant between patient and control groups in terms of age, gender, body mass index and frequency of symptoms (p> 0.05).The mean apnea-hypopnea index (AHI) was 25.1units/hour. We found these parameters significant compared with the control group; apnea-hypopnea index, arousal index, oxygen desaturation index, serum total oxidant and serum total antioxidant level (p<0.05).
The mean serum levels TOS and TAS in patients with OSAS were found 34.2 mmol/L and 1.18 mmol/L, respectively. The mean serum levels TOS and TAS in control group were found 21.7 mmol/L and 1.54 mmol/L, respectively. Differences between two groups were significant (p<0.05).
Conclusion: We observed that increased level of oxidative stress and decreased antioxidant levels in patients with OSAS.


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Article Type: Research Article

J Clin Exp Invest, 2014, Volume 5, Issue 2, 271-275

Publication date: 11 Jun 2014

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Article Downloads: 1037

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