Relationship between total antioxidant capacity and the severity of coronary artery disease
Murat Aydın, Yusuf Selcoki 1 * , Yunus Nazlı, Kadir Serkan Yalçın, Metin Canbal, Bora Demirçelik, Ramazan Yiğitoğlu, Beyhan Eryonucu
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1 Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey* Corresponding Author


Objectives: It was known that oxidative/antioxidative balance shifted to oxidative side in patients with coronary artery disease. The aim of this study is to evaluate the relationship between coronary artery disease and total antioxidant status, oxidative stress index.
Materials and methods: The study group consisted of 87 consecutive patients who were hospitalized for coronary angiography. Plasma total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and oxidative stress index (OSI) was calculated.
Results: The TAC values increased statistically significant in the four tertile compared with the first tertile (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) and the TOS values decreased non- significantly in the four tertile ( 5.2 ± 2.8 vs 7.2 ± 5.4 µmol H2O2 Eq/l) as compared to the patients in the first tertile. According to the number of diseased vessels, plasma oxidative characteristics did not differ between the three groups.
Conclusions: Plasma TAC levels increased in subjects with coronary atherosclerosis and severity of coronary atherosclerosis is related with TAC.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2012, Volume 3, Issue 1, 22-28

Publication date: 13 Mar 2012

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Article Downloads: 1005

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