Relationship between subclinical hypothyroidism and serum homocysteine concentration in premenopausal women
Ayfer Çolak 1 * , Ramazan Avcı, Serkan Yener, Yusuf Kurtulmuş, Mustafa Osman Zengin, Ümit Bozkurt, Füsun Üstüner
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1 Tepecik Eğitim ve Araştırma Hastanesi, Klinik Biyokimya Bölümü, İzmir, Turkey* Corresponding Author


Objective: In our study we aimed to examine serum homocysteine levels of patients without thyroid dysfunctions who have high serum anti thyroid peroxidase (anti-TPO) levels and patients with subclinical hypothyroidism who have high serum thyroid stimulating hormone (TSH) and anti-TPO levels.
Methods: One hundred and seven premenopause female outpatients who referred to endocrine clinic of our hospital were included in our study. We generated 3 groups. First group (Control) consists of 53 (50%) patients between the ages of 30-40 years. Second group (Euthyroid) consists of 31 (29%) patients between the ages of 26-49. Third group (Subclinical Hypothyroidism) consists of 23 (21%) patients between the ages of 33-53 years. Serum total cholesterol, triglycerides, high density lipoprotein (HDL) levels were measured by Olympus 2700 autoanalyzer. Serum TSH, free T4, anti-TPO and homocysteine levels were measured by Siemens Immulite 2000 autoanalyzer.
Results: In our study, total cholesterol, triglycerides, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels were not statistically significantly different among the groups. Although serum homocysteine levels of the third group were higher than the other groups it was not statistically significantly different among the groups.
Conclusion: Serum homocysteine and lipid levels of patients with euthyroidism and subclinical hypothyroidism who have positive anti-TPO levels may be inadequate in assessing the risk of cardiovascular diseases.


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Article Type: Research Article

J Clin Exp Invest, 2013, Volume 4, Issue 3, 293-297

Publication date: 12 Sep 2013

Article Views: 2024

Article Downloads: 938

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