Guillain-Barré syndrome (GBS) usually present with acute inflammatory polyradiculoneuropathy having clinical features of rapid and progressive weakness at the limbs, symmetric decrease or loss of tendon reflexes. The exact mechanism of clinical picture is not well known but immune factors are blamed. Patients having GBS have an recurrence rate ranging between 1% and 10%. Idiopathic thrombocytopenic purpura (ITP) is an acquired systemic disease presented with mild to severe thrombocytopenia. The patient who followed with ITP diagnosis for 12 years underwent 2 times GBS attacks within 2-year interval. We would like to present this case due to rare association of ITP diagnosis & GBS attacks.